李春梅

发布时间:2013-08-06 15:50:45 作者: 浏览次数: 次

  李春梅

1、个人概况

  基本信息:李春梅,女,1984年10月出生,汉族,四川自贡人。中共党员,理学博士,副教授,硕士生导师。

  教学方面:主要承担本科生《药物分析学》、《药物分析学实验》及《药学专业文献检索》等课程,获“2019全国高等学校药学类专业青年教师微课教学大赛”一等奖、“2019全国高等学校药学类专业青年教师教学能力大赛”一等奖。

  研究领域:化学生物传感、药物分析、肿瘤成像与治疗。

  主要开展多功能荧光纳米探针的构建及其在疾病标志物检测、癌细胞成像分析、药物输送及治疗、病毒感染的预防与治疗等方面的研究工作。目前已在国际学术期刊上发表SCI论文60余篇,论文他引2000余次,以第一作者及通讯作者在Advanced Functional Materials、Biomaterials、Analytical Chemistry等刊物发表SCI论文23篇,参与国际专著《Aptamers Selected by Cell-SELEX for Theranostics》的编写。

2、教育及工作经历:

 2016/06-至今:西南大学 药学院, 教师

 2014/03-2016/03,西南大学,生物学博士后流动站,师资博士后

 2011/09-2013/03,美国University of Florida(佛罗里达大学)化学系、生物/纳米交叉研究中心,纳米生物分析,联合培养博士

 2009/09-2013/12,西南大学,分析化学,博士

 2007/09-2009/06,西南大学,药物分析学,硕士(直博)

 2003/09-2007/06,西南大学,应用化学,学士

3.主持的科研项目:

[1] 国家自然科学基金委员会(面上项目),DNA功能化荧光纳米探针用于调控细胞表面核仁素聚集及细胞凋亡成像分析(No. 22074124),2021/01/01-2024/12/31

[2] 中央高校基本业务费人才团队项目(优青),生物传感与纳米医药(No. XDJK2020TY001), 2020/01/01–2022/12/31

[3] 国家自然科学基金(青年科学基金项目),细胞膜成像探针的构建及对病毒-细胞膜结合过程的实时监测(No. 21705131), 2018/01/01–2020/12/31

[4] 中央高校基本业务费一般项目,基于双荧光能量转移构建的肿瘤诊疗一体化纳米探针及其诊疗研究(No. XDJK2018C088),2018/04–2020/12

[5] 重庆市基础科学与前沿技术研究专项项目,基于细胞膜暗场光散射成像研究细胞凋亡过程(cstc2017jcyjAX0167),2017/07/01-2020/06/30

[6] 中国博士后科学基金面上资助(一等),基于细胞表面纳米传感器实时监测病毒早期侵染过程(No. 2015M570760),2015/05–2016/03

[7] 重庆市博士后科研项目特别资助(一等),生物功能化金纳米探针的构建及其广谱抗病毒研究(No. xm2014001),2014/09–2016/02

[8] 中央高校基本业务费一般项目,细胞表面纳米传感器的构建及病毒侵染早期监测(No. XDJK2015C160),2015/05–2016/12

[9] 西南大学博士基金/引进人才计划项目,基于细胞表面荧光成像研究病毒/细胞膜结合过程(No. SWU116058),2016/10–2018/09

[10] 化学生物传感与计量学国家重点实验室(湖南大学)2016年开放课题,基于量子点与金纳米粒子的荧光能量转移监测病毒早期侵染过程(No. 2016003),2017/04–2019/03

4.主要代表论文:

[1] Wang, Y.; He, W.; Li, C. H.; Xia, C.; Yan, Y.; Li, C. M.*; Huang, C. Z*., Chirality transfer of cysteine to the plasmonic resonance region through silver coating of gold nanobipyramids. Chem. Commun., 2021, DOI: 10.1039/d0cc07576k.

[2] Liang, Y.; Yan, Y.; Zou, H. Y.; Yang, T.; Zhen, S. J.; Li, C. M.*; Huang, C. Z., Europium coordination polymer particles based electrospun nanofibrous film for point-of-care testing of copper (II) ions. Talanta, 2021, 228, 122270.

[3] Wang, N.; Jiang, Y. J.; Zhang, X.; Lin, H. R.; Cheng, F.; Li, Q.; Li, C. M.*; Huang, C. Z., Nanosurface energy transfer indicating Exo III-propelled stochastic 3D DNA walkers for HIV DNA detection. Analyst, 2021, 146 (5), 1675-1681.

[4] Jiang, Y. J.; Wang, N.; Cheng, F.; Lin, H. R.; Zhen, S. J.; Li, Y. F.; Li, C. M.*; Huang, C. Z.*, Dual energy transfer-based DNA/graphene oxide nanocomplex probe for highly robust and accurate monitoring of apoptosis-related micrornas. Anal. Chem., 2020, 92 (17), 11565-11572.

[5] Wang, J. R.; Xia, C.; Yang, L.; Li, Y. F.; Li, C. M.*; Huang, C. Z.*, DNA nanofirecrackers assembled through hybridization chain reaction for ultrasensitive SERS immunoassay of prostate specific antigen. Anal. Chem., 2020, 92 (5), 4046-4052.

[6] Cheng, Y. Y.; Xie, Y. F.; Li, C. M.*; Li, Y. F.; Huang, C. Z.*, Förster resonance energy transfer-based soft nanoballs for specific and amplified detection of microRNAs. Anal. Chem., 2019, 91 (17), 11023-11029.

[7] Chai, S. Q.; Lv, W. Y.; He, J. H.; Li, C. H.; Li, Y. F.; Li, C. M.*; Huang, C. Z.*, Dual energy transfer-based fluorescent nanoprobe for imaging miR-21 in nonalcoholic fatty liver cells with low background. Anal. Chem., 2019, 91 (10), 6761-6768.

[8] He, L.; Li, Y.; Wu, Q.; Wang, D. M.; Li, C. M.*; Huang, C. Z.; Li, Y. F.*, Ru(III)-based metal–organic gels: intrinsic horseradish and NADH peroxidase-mimicking nanozyme. ACS Appl. Mater. Inter., 2019, 11 (32), 29158-29166.

[9] Chai, S. Q.; He, J. H.; Zhan, L.; Li, Y. F.; Li, C. M.*; Huang, C. Z.*, Dy(III)-induced aggregation emission quenching effect of single-layered graphene quantum dots for selective detection of phosphate in the artificial wetlands. Talanta, 2019, 196, 100-108.

[10] Liu, M. L.; Chen, B. B.; He, J. H.; Li, C. M.*; Li, Y. F.; Huang, C. Z.*, Anthrax biomarker: An ultrasensitive fluorescent ratiometry of dipicolinic acid by using terbium(III)-modified carbon dots. Talanta, 2019, 191, 443-448.

[11] Cheng, Y. Y.; Li, C. M.*; Mu, R. Z.; Li, Y. F.; Xing, T. T.; Chen, B. B.; Huang, C. Z.*, Dynamically long-term imaging of cellular RNA by fluorescent carbon dots with surface isoquinoline moieties and amines. Anal. Chem., 2018, 90 (19), 11358-11365.

[12] Yang, T.; Li, C. M.*; He, J. H.; Chen, B.; Li, Y. F.; Huang, C. Z.*, Ratiometrically fluorescent dlectrospun nanofibrous film as a Cu2+-mediated solid-phase immunoassay platform for biomarkers. Anal. Chem., 2018, 90 (16), 9966-9974.

[13] Chen, B. B.; Liu, M. L.; Zhan, L.; Li, C. M.*; Huang, C. Z.*, Terbium(III) modified fluorescent carbon dots for highly selective and sensitive ratiometry of stringent. Anal. Chem., 2018, 90 (6), 4003-4009.

[14] He, L.; Jiang, Z. W.; Li, W.; Li, C. M.*; Huang, C. Z.; Li, Y. F.*, In situ synthesis of gold nanoparticles/metal–organic gels hybrids with excellent peroxidase-like activity for sensitive chemiluminescence detection of organophosphorus pesticides. ACS Appl. Mater. Inter., 2018, 10 (34), 28868-28876.

[15] Zheng, L. L.; Li, C. M.*; Zhen, S. J.; Li, Y. F.; Huang, C. Z.*, A dynamic cell entry pathway of respiratory syncytial virus revealed by tracking the quantum dot-labeled single virus. Nanoscale, 2017, 9 (23), 7880-7887.

[16] Zhan, L.; Wu, W. B.; Li, C. M.*; Huang, C. Z.*, Magnetic bead-based sandwich immunoassay for viral pathogen detection by employing gold nanoparticle as carrier. Journal of Analysis and Testing, 2017, 1 (4), 298-305.

[17] Li, C. M.; Zheng, L. L.; Yang, X. X.; Wan, X. Y.; Wu, W. B.; Zhen, S. J.; Li, Y. F.; Luo, L. F.; Huang, C. Z., DNA-AuNP networks on cell membranes as a protective barrier to inhibit viral attachment, entry and budding. Biomaterials, 2016, 77, 216-226.

[18] Li, C. M.; Chen, T.; Ocsoy, I.; Zhu, G. Z.; Yasun, E.; You, M. X.; Wu, C. C.; Zheng, J.;  Song, E. Q.; Huang, C. Z.; Tan, W. H. , Gold-Coated Fe3O4 Nanoroses with Five Unique Functions for Cancer Cell Targeting, Imaging and Therapy. Adv. Funct. Mater.,  2014, 24, 1772-1780.

[19] Li, C. M.; Zhen, S. J.; Wang, J.; Li, Y. F.; Huang, C. Z., A gold nanoparticles-based colorimetric assay for alkaline phosphatase detection with tunable dynamic range. Biosens. Bioelectron., 2013, 43, 366-371.

5. 联系方式

电话:023-68254059

电子邮箱:licm1024@swu.edu.cn

通信地址:重庆市北碚区天生路2号,西南大学药学院,400715