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邹懿
发布时间2013-06-05 16:05:25     作者:    浏览次数: 次

邹懿,博士,研究员。198312月生,籍贯贵州毕节。

  

2002-2009年于西南大学药学院,分别获制药工程学士和微生物与生化药学硕士学位。2013年于上海交通大学微生物代谢国家重点实验室获微生物学博士学位,研究方向为链霉菌来源的复杂结构天然产物生物合成,博士学位论文获上海市优秀博士学位论文奖。2014-2017年,在美国加州大学洛杉矶分校(University of California, Los Angeles, UCLA)从事博士后研究工作,研究方向为真菌来源的复杂结构天然产物生物合成酶学机理研究。近几年来,以第一作者或共第一作者身份在包括Nat. Chem. Biol., Chem. Rev., J. Am. Chem. Soc., Angew. Chem. Int. Edit., Org. Lett.等国际顶级杂志上发表文章数篇。

 

教育与工作经历

2002.09 - 2006.07  西南大学药学院,制药工程,学士

2006.09 - 2009.07  西南大学药学院,微生物与生化药学,硕士

2009.09 - 2013.12  上海交通大学微生物代谢国家重点实验室,微生物学,博士

2014.01 - 2017.01  美国加州大学洛杉矶分校,博士后

       2017.03 - 2017.05  中国医学科学院药物研究所,天然药物活性物质与功能国家重点实验室,课题组长

2017.06 - 至今         西南大学药学院,研究员

 

课题组研究方向

1.    真菌来源的药用天然产物合成生物学与生物酶工程

2.    基于药物靶标基因组挖掘的真菌药用天然产物发现

 

代表性研究论文

1. Zou, Y., Garcia-Borràs, M., Tang, M-C., Hirayama, Y., Li, D., Li, L., Watanabe, K., Houk, K. N.*, Tang, Y.* Enzyme-Catalyzed Cationic Epoxide Rearrangements in Quinolone Alkaloid Biosynthesis. Nat. Chem. Biol. 2017, 13, 325-332. (IF: 15.066). (Recommended as the exceptional paper by F1000 Prime, https://f1000.com/prime/727233646)

2. Tang, M-C.#, Zou, Y.#, Watanabe, K., Walsh, C. T.*, Tang, Y.* Oxidative Cyclization in Natural Product Biosynthesis. Chem. Rev. 2017, 117, 5226-5333. (IF: 47.928). (#co-first author)

3. Zou, Y., Zhan, Z., Li, D., Tang, M-C., Cacho, R., Watanabe, K., Tang, Y.* Tandem Prenyltransferases Catalyze Isoprenoid Elongation and Complexity Generation in Biosynthesis of Quinolone Alkaloids. J. Am. Chem. Soc. 2015, 137, 4980-4983. (IF: 13.858). (Highlighted by Nat. Prod. Rep. 2015, 32, 1165-1169)

4. Zou, Y.#, Xu, W.#, Tsunematsu, Y., Tang, M-C., Watanabe, K., Tang, Y.* Methylation-dependent Acyl Transfer between Polyketide Synthase and Nonribosomal Peptide Synthetase Modules in Fungal Natural Product Biosynthesis. Org. Lett. 2014, 16, 6390-6393. (IF: 6.579). (#co-first author)

5. Zou, Y., Fang, Q., Yin, H., Liang, Z., Kong, D., Bai, L., Deng, Z., Lin, S.* Stereospecific Biosynthesis of β-Methyltryptophan from L-Tryptophan Features a Stereochemical Switch. Angew. Chem. Int. Edit. 2013, 52, 12951-12955. (IF: 11.994)

6. Zou, Y., Yin, H., Kong, D., Deng, Z., Lin, S.* A Trans-acting Ketoreductase in Biosynthesis of a Symmetric Polyketide Dimer SIA7248. ChemBioChem 2013, 14, 679-683. (IF: 2.847)

7. Zhang,Y., Zou, Y., Brock, N. L., Huang, T., Lan, Y., Wang, X., Deng, Z., Tang, Y., Lin, S.* Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily. J. Am. Chem. Soc., 2017, DOI: 10.1021/jacs.7b05517.

8. Liu, N., Hung, Y., Gao, S-S., Hang, L., Zou, Y., Chooi, Y-H.*, Tang, Y.* Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway. Org. Lett. 2017,19, 3560-3563.

9. Bai, J., Yan, D., Zhang, T., Guo, Y, Liu, Y., Zou, Y., Tang, M-C., Liu, B., Wu, Q., Yu, S.*, Tang, Y.*, Hu, Y.* A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A. Angew. Chem. Intl. Ed. 2017, 56, 4782-4786.

10. Li L., Yu, P., Tang, M-C., Zou, Y., Gao S-S., Hung, Y-S., Zhao, M-X., Watanabe, K., Houk, K. N.*, Tang, Y.* Biochemical Characterization of a Eukaryotic Decalin-Forming Diels-Alderase. J. Am. Chem. Soc., 2016, 138, 15837-15840.

11. Yu, X., Liu, F., Zou, Y., Tang, M-C., Hang, L., Houk, K. N.*, Tang, Y.* Biosynthesis of Strained Piperazine Alkaloids- Uncovering the Concise Pathway of Herquline A. J. Am. Chem. Soc. 2016, 138, 13529-13532.

12. Lan, Y., Zou, Y., Huang, T., Wang, X., Brock, N. L., Deng, Z., Lin, S.* Indole Methylation Protects Diketopiperazine Configuration in the Maremycin Biosynthetic Pathway. Sci. China. Chem. 2016, 59, 1224-1228.

13. Kong, D., Zou, Y., Zhang, Z., Xu, F., Brock, N. L., Zhang, L., Deng, Z., Lin, S.* Identification of (2S,3S)-β-Methyltryptophan as the Real Biosynthetic Intermediate of Antitumor Agent Streptonigrin. Sci. Rep. 2016, 6, 20273.

14. Han, M.#, Yin, H.#, Zou, Y., Brock, N. L., Huang, T., Deng, Z., Chu, Y.*, Lin, S.* An Acyl Transfer Reaction Catalyzed by an Epimerase MarH. ACS Catalysis. 2016, 6, 788-792.

15. Tang, M-C., Lin, H-C., Li, D., Zou, Y., Li, J., Xu, W., Cacho, R. A., Hillenmeyer, M., Garg, N. K., Tang, Y.* Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast. J. Am. Chem. Soc. 2015, 137, 13724-13727.

16. Wang, H., Zhang, H., Zou, Y., Mi, Y., Lin, S., Xie, Z., Yan, Y., Zhang, H.* Structural Insight into the Tetramerization of an Iterative Ketoreductase SiaM through Aromatic Residues in the Interfaces. PloS ONE. 2014, 9, e97996.

17. Hu, C.*, Zou, Y., Zhao, W. Effect of Soybean Oil on the Production of Mycelial Biomass and Pleuromutilin in the Shake-flask Culture of Pleurotus mutilis. World. J. Microb. Biot. 2009, 25, 1705-1711.

18. Hu, C.*, Zou, Y. Mutilins Derivatives-From Veterinary to Human-used Antibiotics. Mini-Rev. Med. Chem. 2009, 9, 1397-1406.

 

联系方式

电话:+86 18203018529 E-mail: zouyi31@swu.edu.cn

重庆市北碚区天生路2号,西南大学药学院,202