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陆军
发布时间2013-08-05 11:10:31     作者:陆军    浏览次数: 次

陆军教授,  博士,西南大学药学院药理教研室主任

 

教育经历

1988-1992年 四川大学化学系           学士学位

1992-1995年 四川大学化学系           硕士学位

1995-1998年 中科院长春应用化学研究所  博士学位

 

科研经历

1999-2000年 中科院长春应用化学研究所  助理研究员,

2000-2002年 日本理化学研究所           STAJSPS博士后

2003-2005 年 瑞典卡罗琳斯卡医学院      博士后

2005-2009 年 瑞典卡罗琳斯卡医学院      研究员

2009-2013 年 瑞典卡罗琳斯卡医学院      助理教授

2013-2016 年 瑞典卡罗琳斯卡医学院      高级研究员

20166-  西南大学药学院            教授

20183-  西南大学药学院            药理教研室主任

 

研究内容和成果

主要从事以生物抗氧化体系(硫氧还蛋白体系、谷胱甘肽体系、硒蛋白等)为靶向的新型抗生素、抗癌药物、抗神经退行性疾病的药物作用机制的研究及新药开发。

PNASEMBO Molecular MedicineCancer Research等刊物上发表50余篇SCI论文,被引用3800余次,H-index 27,获1项美国发明专利授权。

 

学术荣誉和兼职

201612月入选重庆市百名海外高层次人才集聚计划,为药学类国际刊物Biomedicine & PharmacotherapyCurrent Pharmaceutical Biotechnology的编委、Current Medicinal Chemistry的客座编辑

 

教学

承担全英文班药理学、分析化学的教学

 

研究组成员及活动

 

 

           陆军 教授

 

 

瑞典皇家科学院院士Arne Holmgren教授访问实验室并在缙云山留影

 

 

英国巴斯大学Chararah Pourzand博士和研究组成员一起郊游

 

 

欢迎有志于新药研究开发的学生、博士后加盟本研究组!

联系地址E-mail:   junlu@swu.edu.cn

代表性文章

1.           Ouyang Y, Peng Y, Li J, Holmgren A, Lu J*. Modulation of thiol-dependent redox system by metal ions via thioredoxin and glutaredoxin systems. Metallomics. 2018, 10(2):218-228. (*通讯作者,下同)

2.           Ren X, Zou L, Lu J, Holmgren A. Selenocysteine in mammalian thioredoxin reductase and application of ebselen as a therapeutic.Free Radic Biol Med. 2018 May 25. pii: S0891-5849(18)30914-6. doi: 10.1016/j.freeradbiomed.2018.05.081.

3.           Zou L, Lu J*, Wang J, Ren X, Zhang L, Gao Y, Rottenberg ME, Holmgren A*. Synergistic antibacterial effect of silver and ebselen against multidrug-resistant Gram-negative bacterial infections. EMBO Mol Med. 2017, 9(8):1165-1178.

4.           Ren X, Zou L, Zhang X, Branco V, Wang J, Carvalho C, Holmgren A, Lu J*. Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System. Antioxid Redox Signal. 2017, 27(13):989-1010

5.           Álvarez-Zaldiernas C, Lu J*, Zheng Y, Yang H, Blasi J, Solsona C*, Holmgren A*. Cellular Redox Systems Impact the Aggregation of Cu, Zn Superoxide Dismutase Linked to Familial Amyotrophic Lateral Sclerosis. J Biol Chem., 2016, 291(33):17197-17208.

6.           Olivera C, Ren X, Vodnala SK, Lu J, Coppo L, Leepiyasakulchai C, Holmgren A, Kristensson K, Rottenberg M, Nitric oxide protects the integrity of the blood-brain barrier during the infection with Trypanosoma brucei, PLoS Pathog, 2016, 12(2): e1005442.

7.  Zhang X, Lu J*, Ren X, Du Y, Zheng Y, Ioannou PV, Holmgren A*, Oxidation of structural cysteine residues in thioredoxin 1 by aromatic arsenicals enhances cancer cell cytotoxicity caused by the inhibition of thioredoxin reductase 1. Free Radic Biol Med. 2015, 89:192-200.

8.  Lu J, Holmgren A, The thioredoxin superfamily in oxidative protein folding, Antioxid Redox Signal, 2014, 457-470.

9.  Lu J*, Holmgren A*, The thioredoxin antioxidant system. Free Radic Biol Med, 2014, 66: 75-87.

10.Lu J, Vodnala SK, Gustavsson AL, Gustafsson TN, Sjöberg B, Johansson HA, Kumar S, Tjernberg A, Engman L, Rottenberg ME, Holmgren A, Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei, J Biol Chem, 2013, 288(38): 27456-27468.

11.Lu J, Vlamis-Gardikas A, Kandasamy K, Zhao R, Gustafsson TN, Engstrand L, Hoffner S, Engman L, Holmgren A, Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione, FASEB J, 2013, 27(4): 1394-1403.

12.Lu J, Holmgren A, Thioredoxin system in cell death progression, Antioxid Redox Signal, 2012, 17(12): 1738-1747.

13.Zhang X, Zheng YJ, Fried LE, Du Y, Montano SJ, Sohn A, Lefkove B, Holmgren L, Arbiser JL, Holmgren A*, Lu J*, Disruption of mitochondrial thioredoxin system as a cell death mechanism of cationic triphenylmethanes, Free Radical Biology & Medicine, 2011, 50(7): 811-20.

14.         Holmgren A, Lu J, Thioredoxin and thioredoxin reductase: Current research with special reference to human disease, BBRC, 2010, 396(1): 120-124.

15.Lu J*, Zhong L, Lönn ME, Burk RF, Hill KE, Holmgren A*, Penultimate selenocysteine residue replaced by cysteine in thioredoxin reductase from selenium-deficient rat liver, FASEB J, 2009, 23(8): 2394-2402.

16.Lu J, Holmgren A, Selenoproteins. J Biol Chem, 2009, 284(2): 723-727.

17.Lu J, Berndt C, Holmgren A, Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase. Biochim Biophys Acta, 2009, 1790(11): 1513-1519.

18.Lu J, Chew EH, Holmgren A, Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide, Proc Natl Acad Sci U S A, 2007, 104(30): 12288-12293.

19.         Papp LV, Lu J, Holmgren A, Khanna KK, From selenium to selenoproteins: Synthesis, identity and their role in human health, Antioxid. Redox Signal, 2007, 9(7): 775-806.

20.         Lu J, Papp LV, Fang J, Rodriguez-Neto S, Zhivotovsky B, Holmgren A, Inhibition of mammalian thioredoxin reductase by some flavonoids: Implications for myricetin and quercetin anticancer activity, Cancer Res, 2006, 66(8): 4410-4418.

 

授权发明专利

Holmgren A, Lu J, Vlamis-Gardikas A, Zhao R, Kandasamy K, Engman L, Engstrand L, Hoffner S. Bacterial thioredoxin reductase inhibitions and methods for use thereof. U.S. Patent, patent No.: US 2014/0088149 A1. Patent open date2014.3.27.