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辛文宽
发布时间2013-09-01 11:10:59     作者:    浏览次数: 次

辛文宽

博士,教授,博士导师

教育经历

1993/9 - 1996/7 北京大学,理学博士 

1990/9 - 1993/7 兰州大学,理学硕士 

1983/9 - 1987/7 兰州大学,理学学士

工作经历

2015/9-               西南大学,药学院,教授,博士导师

2011/6 - 2015/8 美国 南卡罗来纳大学,药学院,副教授

2005/12 - 2011/5 美国 南阿拉巴马大学,医学院,研究员

2004/5 - 2005/11 美国 德克萨斯大学医学中心,休斯顿,副研究员

2000/1 - 2004/4 加拿大 多伦多大学,副研究员

1996/9 - 1999/5 美国 俄克拉荷马大学,博士后

1987/8- 1990/7 中国 兰州大学,助教

*2009/12   被兰州大学聘为教授,博士导师

*入选2015年度重庆市“百名海外高层次人才集聚计划”

个人专长

科研:接受到良好的化学教育,出师于高小霞院士并获得北京大学理学博士学位。毕业后受到高水平、多学科的训练,包括生物分析化学、神经科学、生理学和药理学。具有长期从事细胞膜离子通道动力学、生物分子信号传导、神经、心肌、平滑肌生理和药理学研究的经历。精通confocal microcopy(共聚焦显微镜光学), patch clamp electrophysiology (细胞膜片钳电生理学)研究领域及科研成果包括NMDA离子通道在记忆和疼痛控制中的生理调控机制,G-protein-coupled receptor (GPCR) and phosphodiesterase (PDE)控制的信号传导及其对心肌和平滑肌功能的调节。能够综合应用化学、神经科学、生理学、药理学的知识和技能开展多学科交叉领域的研究

具有多年与著名泌尿科专家(Dr. Rovner, E.S., Medical University of South Carolina, the President of Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction, USA) 合作,利用系统药理学策略(Systems Pharmacology)对人的活体膀胱组织进行生理、药理学研究的经历。此类研究的优势和特点是通过综合分析实验室数据与病人的有关疾病信息,使其所获结果最能反映人的膀胱机能调节和致病机理,为开发更有效的治疗药物提供最为相关的实验依据。

近期的一项研究阐释了H2S如何增加乙酰胆碱分泌、平滑肌激活和伸缩能力(Novel mechanism of hydrogen sulfide-induced guinea pig urinary bladder smooth muscle contraction: the role of BK channels and cholinergic neurotransmission. Am. J. Physiol. Cell Physiol. C107-116, 2015)。此项研究获得2015SUFU meeting (The Society for Urodynamics and Female Urology) (Feb. 24-28, 2015, Scottsdale, AZ ,USA)最佳基础科学研究奖。

Xin, W., Feinstein, W. P., Britain, A. L. et al.: Estimating the magnitude of near-membrane PDE4 activity in living cells. Am J Physiol Cell Physiol, 309: C415, 2015 was selected by APSselect in October 2015.  (http://apsselect.physiology.org/archives-2015#october)

(201510月,该文章被美国生理学会选为最佳原始研究。美国生理学会每月从其出版的十个科学研究杂志中选出最杰出的独创性研究论文收集在APSselect)

教学:领衔建设本科药学全英文专业,按国际化标准制定并实施建设方案,最终建成药学博士专业 (Doctor of Pharmacy)。在美国高校接受到多方面的教学理论与实践能力的培训。具有丰富的美国大学教学和培养研究生、博士生、博士后和年轻研究人员的经历。参与研究生核心课程的授课,指导和参与指导多名研究生的培养。

科研团队建设:现有教授、副教授和讲师四人,都有理学或临床医学博士学位,在读研究生六人。积极扩充科研团队,从广泛领域中引进多方面人才,打造研究平台,推动与海外著名大学和科研机构研究生/博士后、访问学者的联合培养。实验室新购进总值近400百万元的仪器设备,配备当今国际上最为先进的Nikon A1+R激光共聚焦和电生理学综合系统。Qtower 2.2实时荧光定量PCR仪,并能够利用少量(10-15个)单细胞进行微量蛋白质定量分析DMT 750TOBS 系统用于平滑肌(血管及非血管) 、心肌及其它离体组织样本的生理及病理学研究。学院分析测试中心配备各类先进的设备。

招收研究生、博士生、博士后和年轻教师,领域涉及药理学、生理学、病理学、神经科学、细胞和分子生物学、天然有机化学、蛋白质化学、药物化学、现代医学和传统中医学。

PhD Students, Postdoctoral Associates, and Junior Faculty are welcome to join our group.

We welcome applicants who have an interest and excellent training in anyone of the following fields: pharmacology, fundamental cell biology, molecular and cellular mechanisms underlying the physiology and pathophysiology of human diseases, organic, protein, and medicinal chemistry, modern medicine, and traditional Chinese medicine. 

We are interested in ion channel physiology and pharmacology; pharmacology of natural compounds from traditional medicinal herbs; phosphodiesterase (PDE) and G-protein coupled receptor (GPCR) signal transduction, their regulation of synaptic transmission at the neuromuscular junction as well as the regulation of smooth muscle and cardiac muscle function. We have well-designed laboratory spaces, a new state-of-the-art Center for Cellular Imaging and Electrophysiology systems,  and have full access to core facilities. 

Book Chapter

Rich, T.C., Xin, W.K., Leavesley, S.J., and Taylor, M. 2015. Chapter 6: Channel based reporters for cAMP detection. In: cAMP Signaling. M. Zaccolo Ed.. Springer Science+ Business Media New York.

Selected Publications

1. Xin W, Li N, Fernandes VS, Chen B, Rovner ES, and Petkov GV. BK channel regulation by phosphodiesterase type 1: A novel signaling pathway controlling human detrusor smooth muscle function. Am J Physiol Renal Physiol, 2016.PMID: 26911851

2. Xin W.K., Feinstein WP, Britain AL, Ochoa CD, Zhu B, Richter W, Leavesley SJ, Rich TC. 2015 Estimating the magnitude of near-membrane PDE4 activity in living cells. Am. J. Physiol. Cell Physiol. 309: C415, 2015. 

This article was selected by APSselect, Oct. 2015. “Each month, the most outstanding recently published papers from our ten research journals are selected and made available through this multi-journal website.” http://apsselect.physiology.org/

3. Fernandes, V. S.#, Xin, W.K.#, and Petkov, G.V.* 2015. Novel mechanism of hydrogen sulfide-induced guinea pig urinary bladder smooth muscle contraction: The role of BK channels and cholinergic neurotransmission. Am. J. Physiol. Cell Physiol. PMID: 25948731. 

4. Xin, W.K., Li, N., Cheng, Q.P., Fernandes, V. S., and Petkov, G.V. 2014. Constitutive PKA activity is essential for maintaining the excitability and contractility in guinea pig urinary bladder smooth muscle: Role of the BK channel.  Am. J. Physiol. Cell Physiol. 307(12): C1142–C1150.

5. Xin, W.K., Li, N., Cheng, Q.P., and Petkov, G.V. 2014. BK channel-mediated relaxation of urinary bladder smooth muscle: A novel paradigm for phosphodiesterase type 4 regulation of bladder function. J. Pharmacol. Exp. Ther. 349(1):56-65. 

Figure 1 was selected as the Cover Caption of April 2014 issue.

6. Parajuli, S.P., Hristov, K.L., Sullivan, M.N., Xin, W.K., Smith, A.C., Earley, S., Malysz, J., and Petkov, G.V. 2013. Control of Urinary Bladder Smooth Muscle Excitability by the TRPM4 channel modulator 9-phenanthrol. Channels (Austin). 7(6): 537-540.

7. Smith, A.C., Hristov, K.L., Cheng, Q.P., Xin, W.K., Earley, S., Malysz, J., and Petkov, G.V. 2013. Novel role for the transient potential receptor melastatin 4 (TRPM4) channel in guinea pig detrusor smooth muscle excitation-contraction coupling. Am. J. Physiol. Cell Physiol. 304(5): C467-C477. 

8. Smith, A.C., Parajuli, S.P., Hristov, K.L., Cheng, Q.P., Soder, R.P., Afeli, S.A.Y., Earley, S., Xin, W.K., Malysz, J., and Petkov, G.V. 2013. TRPM4 channel: A New Player in Urinary Bladder Smooth Muscle Function in Rats. Am. J. Physiol. Renal Physiol. 304(7): F918-F929.

9. Xin, W.K., Soder, R.P., Cheng, Q.P., Rovner, E.S., and Petkov, G.V. 2012. Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor mediated BK channel activation. Am. J. Physiol. Cell Physiol. 303(10): C1079-C1089.

10. Xin, W.K., Cheng, Q.P., Soder, R.P., Rovner, E.S., and Petkov, G.V. 2012. Constitutively active phosphodiesterase activity regulates urinary bladder smooth muscle function: Critical role of KCa1.1 channel.  Am. J. Physiol. Renal Physiol. 303(9): F1300-F1306.

11. Horvat S.J., Deshpande D.A., Yan H, Panettieri R.A., Codina J, Dubose T.D., Jr., Xin W.K., Rich T.C., and Penn R.B. 2012. A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle. FASEB J. 26(9):3670-3679.

12. Xin, W.K., Cheng, Q.P., Soder, R.P., and Petkov, G.V. 2012. Inhibition of phosphodiesterases relaxes detrusor smooth muscle via activation of the large conductance voltage- and Ca2+-activated K+ channel. Am. J. Physiol. Cell Physiol. 302(9):C1361-C1370.

13. Xin W.K., Yang X., Rich T.C., Krieg T., Barrington R., Cohen M.V., and Downey J.M. 2012. All Preconditioning-Related G Protein-Coupled Receptors Can be Demonstrated in the Rabbit Cardiomyocyte. J Cardiovasc. Pharmacol. Ther. 17:190-198.

14. Yang X., Xin W.K., Yang X.M., Kuno A., Rich T.C., Cohen M.V., and Downey J.M. 2011. A2B adenosine receptors inhibit superoxide production from mitochondrial complex I in rabbit cardiomyocytes via a mechanism sensitive to Pertussis toxin. Br J Pharmacol 163:995-1006.

15. Xin, W.K., Tran, T.M., Richter, W., Clark, R.B., and Rich, T.C. 2008. Roles of GRK and PDE4 activities in the regulation of β2-adrenergic signaling. J. Gen. Physiol. 131(4):349-364.

16. Rich, T.C., Xin, W.K., Mehats, C., Hassell, K.A., Piggott, L.A., Le, X., Karpen, J.W., and Conti, M. 2007. Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells. Am. J. Physiol. Cell Physiol. 292:319-331.

17. Xin, W.K., Zhao, X.H., Xu, J., Lei, G., Kwan, C.L., Zhu, K.M., Cho, J.S., Duff, M., Ellen, R.P., McCulloch, C.A., and Yu, X.M. 2005. The removal of extracellular calcium: a novel mechanism underlying the recruitment of N-methyl-D-aspartate (NMDA) receptors in neurotoxicity. Eur. J. Neurosci. 21:622-636.

18. Xin, W.K., Kwan, C.L., Zhao, X.H., Xu, J., Ellen, R.P., McCulloch, C.A., and Yu. X.M. 2005. A functional interaction of sodium and calcium in the regulation of NMDA receptor activity by remote NMDA receptors. J. Neurosci. 25:139-148.

19. Xin, W.K., Shen, X.M., Li, H., and Dryhurst, G. 2000. Oxidative metabolites of 5-S-cysteinylnorepinephrine are irreversible inhibitors of mitochondrial complex I and the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complex: possible implications for neurodegenerative brain disorders. Chem. Res. Toxicol. 13:749-760.

20. Zhuang, Q.K., Dai, H.C., Gao, X.X., and Xin, W.K. 2000. Electrochemical studies of the effect of lanthanide ions on the activity of glutamate dehydrogenase. Bioelectrochem. 52:37-41.

21. Xin, W.K., Gao, X.X. 1996. The study of the effect of lanthanide ions on the kinetics of glutamate dehydrogenase by chronoamperometric method. Analyst 121:687-690.

22. Xin, W.K., Gao, X.X. 1996. A chronoamperometry method for study on effect of lanthanide ions on glutamate dehydrogenase. Chin. Sci. Bull., 4(12).

23. Xin, W.K., Jiang, Z.W., Gao, X.X. 1995. The function of rare earth ions on "ion-gate" of the glutathione monolayer gold electrode. Chin. Chem. Lett., 6(6), 513-516.

 Contact email: xinwenkuan@swu.edu.cn电话:023-6825-1479