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Wenkuan Xin,Ph.D.

Professor of Pharmacology

College of Pharmaceutical Sciences,

Southwest University, Chongqing 400716, P. R. China

Ph: 86-136-5764-5079, 023-6825-1479

Email: xinwenkuan@swu.edu.cn

 

 

Education

 

·   Ph.D. in Chemistry, Peking University, China 1996

·   M.S. in Chemistry, Lanzhou University, China 1993

·   B.S. in Chemistry, Lanzhou University, China 1987

 

Academic Positions

 

·   Professor of Pharmacology, College of Pharmaceutical Sciences, Southwest University, Chongqing, China 2015-

·   Research Assistant Professor, South Carolina College of Pharmacy, University of South Carolina 2011-2015

·   Research Instructor, University of South Alabama College of Medicine 2006-2011     

·   Research Associate, University of Texas Health Sciences Center at Houston, Houston, Texas 2004-2005

·   Research Associate, University of Toronto, Canada 2000-2004

·   Postdoctoral Fellow, biochemistry, neuronal toxicity, University of Oklahoma, Norman, Oklahoma 1996-1999

 

 

The focus of current work

 

·   Setting up the International Collaboration Research Centre For Cardiovascular Physiology And Pharmacology. After 20-years working in North America, I moved back to China from USA as an American citizen in 2015; since then I have been engaging in setting up the research center. The goal of the center is to promote international collaboration on basic science and clinical research.

·   The Southwest University, the Administration of Foreign Experts Affairs of Chongqing, and State Administration of Foreign Experts Affairs have been supporting our projects. With the grant support, we are able to invite Clinical cardiologists from the University of Cambridge, UK, Clinical Pharmacists, Physiologist, and Pharmacologists from Germany, Sweden, United States, Canada, Spain, and India, to Southwest University for collaboration on various research projects.

·   Join application for a research grant from the Ministry of Science and Technology of the People´s Republic of China: This grant supports the collaboration research carried out by the institutes from China, and other members of BRICS. The objective of this project is to determine the physiological function of bitter taste receptors, a family of G-protein coupled receptors, in cardiovascular system, and the potential clinical application of their agonists for the treatment of cardiovascular diseases.

 

Expertise

     ·   Patch clamp electrophysiology

·   Confocal microscopy and live-cell imaging

·   Immunochemistry and immunoassay

·   Immunocytochemistry and immunohistochemistry; molecular biology

 

Research Interests

·   Phosphodiesterase (PDE) and G-protein coupled receptor (GPCR) signal transduction and their regulation of smooth muscle and cardiac muscle function.

·   Synaptic transmission at the neuromuscular junction and its regulation of smooth muscle function with aging.

·   Ion channel physiology and pharmacology.

 

Current research Projects

 

The current research projects include but not limited to GPCRs, ion channels, PDEs in cardiac and vascular physiology:

·   Understand the mechanisms of signaling by GPCRs, particularly the bitter taste receptors, a sub family members of GPCRs.

·   Define the molecular mechanisms that stabilize and maintain sinoatrial node functions, the molecular mechanisms for cardiac muscle dysfunction in heart failure.

·   Characterize the structures and molecular mechanisms of the function of bitter taste receptors in the heart and cardiac vessels. 

·   Identify the endogenous agonists of bitter taste receptors

·   Discover nature compounds from medicinal herbs as the bitter taste receptor agonists and research their potential implication in the treatment of cardiovascular diseases.

Laboratory Instruments: Nikon A1R+ Confocal microscope configured with Ti-E capturing high-quality confocal images at ultrahigh-speed and enhanced sensitivity with a resonant scanner and Galvano scanner; MDC (AXON) electrophysiology systems including 700B and 900A amplifiers; DMT 750TOBS Tissue/Organ Bath System with DMT CS4 stimulator; DMT 900MH-F Langendorff Heart Perfusion System, Analytik-jenaq AG qTOWER 2.2 real-time PCR system.

      A list of available equipment is attached.

 

Book Chapter

Rich, T.C., Xin, W.K., Leavesley, S.J., and Taylor, M. 2015. Chapter 6: Channel based reporters for cAMP detection. In: cAMP Signaling. M. Zaccolo Ed.. Springer Science+ Business Media New York. •ISBN 978-1-4939-2537-7

 

Selected Publications

 

1.      Wang W., Duclot F., Groveman R.B., Carrier N., Qiao H.F., Fang X.Q., Wang H., Xin W.K., Jiang X.H., Salter W.M., Ding X.S., Kabbaj M., Yu X.M. 2018. Hippocampal protein kinase D1 is necessary for DHPG-induced learning and memory impairments in rats. PLoS One, 13 (4): e0195095

2.      Xin W.K., Li N, Fernandes VS, and Petkov GV. 2016. Constitutively active PKA regulates neuronal acetylcholine release and contractility of guinea pig urinary bladder smooth muscle. Am J Physiol Renal Physiol, 310. F1377-84.

3.      Xin W.K., Li N, Fernandes VS, Chen B, Rovner ES, and Petkov GV. 2016. BK channel regulation by phosphodiesterase type 1: A novel signaling pathway controlling human detrusor smooth muscle function. Am J Physiol Renal Physiol, 310. F994-9.

4.      Xin W.K., Feinstein WP, Britain AL, Ochoa CD, Zhu B, Richter W, Leavesley SJ, Rich TC. 2015 Estimating the magnitude of near-membrane PDE4 activity in living cells. Am. J. Physiol. Cell Physiol. 309: C415, 2015.

This article was selected by APSselect, Oct. 2015. “Each month, the most outstanding recently published papers from our ten research journals are selected and made available through this multi-journal website.” http://apsselect.physiology.org/

5.      Fernandes, V. S.#, Xin, W.K.#, and Petkov, G.V.  2015. Novel mechanism of hydrogen sulfide-induced guinea pig urinary bladder smooth muscle contraction: The role of BK channels and cholinergic neurotransmission. Am. J. Physiol. Cell Physiol. 309. C107-116.

6.      Fang, X. Q., Qiao, H., Groveman, B. R., Feng, S., Pflueger, M., Xin, W. K., Ali, M. K., Lin, S. X., Xu, J., Duclot, F., Kabbaj, M., Wang, W., Ding, X. S., Santiago-Sim, T., Jiang, X. H., Salter, M. W. & Yu, X. M. 2015. Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors. Mol Brain 8:75.

7.      Xin, W.K., Li, N., Cheng, Q.P., Fernandes, V. S., and Petkov, G.V. 2014. Constitutive PKA activity is essential for maintaining the excitability and contractility in guinea pig urinary bladder smooth muscle: Role of the BK channel.  Am. J. Physiol. Cell Physiol. 307(12): C1142–C1150.

8.      Xin, W.K., Li, N., Cheng, Q.P., and Petkov, G.V. 2014. BK channel-mediated relaxation of urinary bladder smooth muscle: A novel paradigm for phosphodiesterase type 4 regulation of bladder function. J. Pharmacol. Exp. Ther. 349(1):56-65.

      Figure 1 was selected as the Cover Caption of April 2014 issue.

9.      Parajuli, S.P., Hristov, K.L., Sullivan, M.N., Xin, W.K., Smith, A.C., Earley, S., Malysz, J., and Petkov, G.V. 2013. Control of Urinary Bladder Smooth Muscle Excitability by the TRPM4 channel modulator 9-phenanthrol. Channels (Austin). 7(6): 537-540.

10.  Smith, A.C., Hristov, K.L., Cheng, Q.P., Xin, W.K., Earley, S., Malysz, J., and Petkov, G.V. 2013. Novel role for the transient potential receptor melastatin 4 (TRPM4) channel in guinea pig detrusor smooth muscle excitation-contraction coupling. Am. J. Physiol. Cell Physiol. 304(5): C467-C477.

11.  Smith, A.C., Parajuli, S.P., Hristov, K.L., Cheng, Q.P., Soder, R.P., Afeli, S.A.Y., Earley, S., Xin, W.K., Malysz, J., and Petkov, G.V. 2013. TRPM4 channel: A New Player in Urinary Bladder Smooth Muscle Function in Rats. Am. J. Physiol. Renal Physiol. 304(7): F918-F929.

12.  Xin, W.K., Soder, R.P., Cheng, Q.P., Rovner, E.S., and Petkov, G.V. 2012. Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor mediated BK channel activation. Am. J. Physiol. Cell Physiol. 303(10): C1079-C1089.

13.  Xin, W.K., Cheng, Q.P., Soder, R.P., Rovner, E.S., and Petkov, G.V. 2012. Constitutively active phosphodiesterase activity regulates urinary bladder smooth muscle function: Critical role of KCa1.1 channel.  Am. J. Physiol. Renal Physiol. 303(9): F1300-F1306.

14.  Horvat S.J., Deshpande D.A., Yan H, Panettieri R.A., Codina J, Dubose T.D., Jr., Xin W.K., Rich T.C., and Penn R.B. 2012. A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle. FASEB J. 26(9):3670-3679.

15.  Xin, W.K., Cheng, Q.P., Soder, R.P., and Petkov, G.V. 2012. Inhibition of phosphodiesterases relaxes detrusor smooth muscle via activation of the large conductance voltage- and Ca2+-activated K+ channel. Am. J. Physiol. Cell Physiol. 302(9):C1361-C1370.

16.  Xin W.K., Yang X., Rich T.C., Krieg T., Barrington R., Cohen M.V., and Downey J.M. 2012. All Preconditioning-Related G Protein-Coupled Receptors Can be Demonstrated in the Rabbit Cardiomyocyte. J Cardiovasc. Pharmacol. Ther. 17:190-198.

17.  Yang X., Xin W.K., Yang X.M., Kuno A., Rich T.C., Cohen M.V., and Downey J.M. 2011. A2B adenosine receptors inhibit superoxide production from mitochondrial complex I in rabbit cardiomyocytes via a mechanism sensitive to Pertussis toxin. Br J Pharmacol 163:995-1006.

18.  Xin, W.K., Tran, T.M., Richter, W., Clark, R.B., and Rich, T.C. 2008. Roles of GRK and PDE4 activities in the regulation of β2-adrenergic signaling. J. Gen. Physiol. 131(4):349-364.

19.  Rich, T.C., Xin, W.K., Mehats, C., Hassell, K.A., Piggott, L.A., Le, X., Karpen, J.W., and Conti, M. 2007. Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells. Am. J. Physiol. Cell Physiol. 292:319-331.

20.  Xin, W.K., Zhao, X.H., Xu, J., Lei, G., Kwan, C.L., Zhu, K.M., Cho, J.S., Duff, M., Ellen, R.P., McCulloch, C.A., and Yu, X.M. 2005. The removal of extracellular calcium: a novel mechanism underlying the recruitment of N-methyl-D-aspartate (NMDA) receptors in neurotoxicity. Eur. J. Neurosci. 21:622-636.

21.  Xin, W.K., Kwan, C.L., Zhao, X.H., Xu, J., Ellen, R.P., McCulloch, C.A., and Yu. X.M. 2005. A functional interaction of sodium and calcium in the regulation of NMDA receptor activity by remote NMDA receptors. J. Neurosci. 25:139-148.

22.  Xin, W.K., Shen, X.M., Li, H., and Dryhurst, G. 2000. Oxidative metabolites of 5-S-cysteinylnorepinephrine are irreversible inhibitors of mitochondrial complex I and the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complex: possible implications for neurodegenerative brain disorders. Chem. Res. Toxicol. 13:749-760.

23.  Zhuang, Q.K., Dai, H.C., Gao, X.X., and Xin, W.K. 2000. Electrochemical studies of the effect of lanthanide ions on the activity of glutamate dehydrogenase. Bioelectrochem. 52:37-41.

24.  Xin, W.K., Gao, X.X. 1996. The study of the effect of lanthanide ions on the kinetics of glutamate dehydrogenase by chronoamperometric method. Analyst 121:687-690.

25.  Xin, W.K., Gao, X.X. 1996. A chronoamperometry method for study on effect of lanthanide ions on glutamate dehydrogenase. Chin. Sci. Bull., 4(12).

26.  Xin, W.K., Jiang, Z.W., Gao, X.X. 1995. The function of rare earth ions on "ion-gate" of the glutathione monolayer gold electrode. Chin. Chem. Lett., 6(6), 513-516.

       

Presentations on International Conferences

 

1.Xin, W.K., Wang, T., Jing, Y., and Fernandes, V.S. 2018. The novel mechanism of bitter taste receptors attenuating rat ventricular contractility. FASEB J. 32: 839.10

2.Xin, W.K. and Chen Q. 2017. The Cellular Mechanism of Bitter Taste Receptor Mediated Relaxation of Rat Aorta. FASEB J. 31: 672.5

3.Xin, W.K., Li, N., Rovner, E., Cheng, Q.P., and Petkov, G.V. 2014. Role of phosphodiesterase-1 in muscarinic receptor-induced human urinary bladder smooth muscle excitability and contractility. FASEB J. 28: 865.4

4.Xin, W.K., Cheng, Q.P., Li, N., and Petkov, G.V. 2013. Constitutively active phosphodiesterase type 4 controls large conductance Ca2+-activated K+ channel activity in guinea pig detrusor smooth muscle. FASEB J.  27:923.4

5.Xin, W.K., Cheng, Q.P., Soder, R.P., and Petkov, G.V. 2012. Inhibition of phosphodiesterases relaxes urinary bladder smooth muscle via activation of the large conductance voltageand Ca2+-activated K+ channels, FASEB J. 26:1140.10.

6.Xin, W.K., Cohen, M.V., Rich, T.C., Downey, J.M. 2009. Which preconditioning-associated G-protein coupled receptors are expressed on the sarcolemma? FASEB J. 23: 793.25.

7.Xin, W.K., Liu, Y.P., Cohen, M.V., Downey, J.M., Rich, T.C. 2009. Regulation of basal cAMP levels in rabbit cardiomyocytes. FASEB J. 23: 582.2

8.Rich, T.C., Zhu, B., Xin, W.K. 2008. Estimating the magnitude of PDE4 activity near the plasma membrane of HEK-293 cells. FASEB J. 22:836.2.

9.Rich, T.C., Xin, W.K., Britain, A.L., Karpen, J.W. 2007. Functional segregation of prostaglandin- and isoproterenol-induced cAMP signals. FASEB J. 21:A792.

10.  Rich, T.C., Vayttaden, S.J., Clark, R.B., Xin, W.K. 2007. GRK and PDE4 activities underlie sustained suppression of b2-adrenergic signals. FASEB J. 21:A791.

11.  Rich, T.C., Xin, W.K., Mehats, C., Hassell, K.A., Piggott, L.A., Le, X., Karpen, J.W., Conti, M. 2006. PKA-mediated stimulation of PDE4 activity in conjunction with diffusional barriers and buffering regulate transient cAMP signals near the plasma membrane of HEK-293 cells. Biophys. J. 90.

12.  Xin, W.K. and Rich, T.C. 2006. The roles of phosphodiesterase activity and receptor desensitization in shaping cyclic nucleotide signals. AHA Research Symposium 64A.

13.  Xue, S., Xin, W.K, Liu, Q., Kwan, C.L., Yu, X. M. 2005. Mood stabilizers induce a use-dependent rundown of NMDA receptor currents. Soc. for Neurosci. 842.10.

14.  Zhao, X.H., Xin, W.K., Xu, J., Kwan, C.L., Yu, X.M. 2004. The recruitment of N-methyl-D-Aspartate receptor activity in neurotoxicity. Soc. for Neurosci., 460.2.

15.  Xin, W.K., Kwan, C. L., Yu, X.M. 2003. The regulation of NMDA receptor activity by remote NMDA receptors. Soc. for Neurosci. 795. 9.

16.  Xu, J., Xin, W.K., Kwan, C.L., Yu, X.M. 2002. The role of sodium in extracellullar calcium reduction-induced neuronal death and up-regulation of NMDA single channel gating. Soc. for Neurosci. 245.9.

 

 

International collaboration Research

Laboratory for Cardiovascular Physiology and Pharmacology

 

The laboratory is supported by

       Southwest University

       The Office of International Affairs at Southwest University

       The Administration of Foreign Experts Affairs of Chongqing

       The Administration of Foreign Experts Affairs of China

 

        The International Collaboration Research Laboratory for Cardiovascular Physiology and Pharmacology grant from The Administration of Foreign Experts Affairs of China supports the development of sustainable collaborative partnerships between outstanding researchers in China and the best research groups all over the world. Our aim is to attract outstanding international scientists and their teams to work with scientists at the Southwest University and to develop new approaches to the prevalent cardiovascular diseases including high blood pressure and heart failure.

       The current research projects include but not limited to G-protein-coupled receptors (GPCRs), ion channels, phosphodiesterases (PDEs) in cardiac and vascular physiology:

·         Understand the mechanisms of signaling by GPCRs, particularly the bitter taste receptors, a sub family members of GPCRs.

·         Characterize the structures and molecular mechanisms of the function of bitter taste receptors in the heart and cardiac vessels. 

·         Define the molecular mechanisms that stabilize and maintain sinoatrial node functions, the molecular mechanisms for cardiac muscle dysfunction in heart failure.

·         Identify the endogenous agonists of bitter taste receptors

·         Discover nature compounds from medicinal herbs as the bitter taste receptor agonists and research their potential implication in the treatment of hypertensive heart diseases.

 

Grants (in million RMB ¥)

1.      The International Collaboration Research Laboratory for Cardiovascular Physiology and Pharmacology            

Administration of Foreign Experts Affairs of China

                                                                BC2018042; 06.2018 – 05.2019          0.45

               with matching found from SWU                                                                      0.45

               this grant is renewable for 5 years.

2.      The G-protein-coupled bitter taste receptors and phosphodiesterase in cardiovascular system and novel drug discovery

Southwest University 104290/22300503; 01.2018 – 12.2020                             0.90                       

3.      The G-protein-coupled bitter taste receptors and phosphodiesterase in cardiovascular system and novel drug discovery

            Southwest University SWU 115086; 09.2015 – 08.2020                                       6.50

4.      International collaboration program for undergraduate education

Administration of Foreign Experts Affairs of Chongqing

                                                                01.2017 – 12.2017                               0.1

 

The leading Scientist at Southwest University

Chengzhi Huang, Ph.D.

Professor of Pharmaceutical Analysis

College of Pharmaceutical Sciences and Chinese Medicine

Southwest University, Chongqing 400716, P. R. China

 

The leading scientist of international collaborators

Georgi Petkov, Ph.D. 

Harriet S. Van Vleet Professor

Professor & Chairman

Department of Pharmaceutical Sciences

College of Pharmacy

The University of Tennessee Health Science Center, Memphis, TN, USA

http://www.uthsc.edu/pharmacy/about/faculty-and-staff.php#pharmscifaculty

Dr. Petkov’s research: the mechanisms that regulate smooth muscle function and the role of membrane ion channels in this cell type; the modulation of excitation-contraction coupling in various types of smooth muscle, including vascular, gastrointestinal and urinary bladder.

 

Members associated with the laboratory at Southwest University

Changhua Hu, Ph.D.

Professor and Dean

College of Pharmaceutical Sciences and Chinese Medicine

Southwest University, Chongqing 400716, P. R. China

Sanjib Bhattacharyya, Ph.D.

Professor

College of Pharmaceutical Sciences and Chinese Medicine

Southwest University, Chongqing 400716, P. R. China

Ming Ma, Ph.D.

Professor

College of Life Sciences

Southwest University, Chongqing 400716, P. R. China

Dacheng Yang, Ph.D.

Professor

School of Chemistry & Chemical Engineering

Southwest University, Chongqing 400716, P. R. China

Jun Lu, Ph.D.

Professor of Pharmacology

College of Pharmaceutical Sciences and Chinese Medicine

Southwest University, Chongqing 400716, P. R. China

 

Members associated with the laboratory at ChongqingUniversity

       Xue Weiwei, Ph.D.

       Associate Professor

       College of Pharmacy

       Chongqing University, Chongqing

       http://sps.cqu.edu.cn/info/1116/1417.htm

 International members associated with the laboratory

Jonathan H. Jaggar, Ph.D.

Maury W. Bronstein Endowed Professor

Department of Physiology

The University of Tennessee Health Science Center, Memphis, TN, USA

            http://www.uthsc.edu/physiology/faculty/jjaggar.php

Dr. Jaggar’s research program investigates the regulation of arterial contractility and systemic blood pressure by ion channels that are expressed in arterial smooth muscle and endothelial cells.

Thomas Krieg, M.D.

Department of Medicine

University of Cambridge

Addenbrooke’s Hospital

Cambridge, United Kingdom

http://www.med.cam.ac.uk/krieg/

Dr. Krieg’s research: A heart attack occurs when a blood clot forms in a coronary artery depriving blood flow from a region of the heart, a condition termed ischemia. Current therapy is to reopen the artery but blood flow is seldom restored before a significant amount of the heart muscle has died. Because lost heart muscle cannot be regenerated the patient is left with a weakened heart and heart failure often occurs. Our research is directed toward identifying therapies that prevent cell death in ischemic heart and the subsequent development of heart failure.

Scott Earley, Ph.D.

Professor of Pharmacology

Department of Pharmacology

University of Nevada, Reno School of Medicine

Reno, NV 89557-0318, USA

https://med.unr.edu/directory/scott-earley?v=bio#Biography

      

Dr. Earley’s lab is focused on elucidating the functional significance of the transient receptor potential (TRP) superfamily of cation channels in the cerebral vasculature and other organ systems. The mammalian TRP superfamily is composed of 28 distinct gene products assigned to six subfamilies based on sequence homology. TRP channels act as fundamental sensors of the environment at the cellular level and mediate appropriate responses to stimuli such as light, pressure, temperature, changes in osmolarity, and certain chemical agonists. Although prominent in sensory neurons, multiple TRP channels are present in most types of cells. We are primarily interested in learning how TRP channels are involved in smooth muscle excitability and contractility, endothelium-dependent vasodilation, and cellular proliferation during pathophysiological conditions.

Bernd Meibohm, Ph.D.

Associate Dean, Graduate Programs and Research

Professor

Pharmaceutical Sciences

College of Pharmacy, UTHS

The University of Tennessee Health Science Center, Memphis, TN, USA

http://www.uthsc.edu/pharmacy/about/faculty-and-staff.php#pharmscifaculty

Dr. Meibohm’s research is focused on the investigation of the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs with special emphasis on PK/PD-correlations.

Steven C. Laizure, Pharm.D.

Professor,

Board Certified Pharmacotherapy Specialist

Pharmacy licenses in North Carolina and Tennessee

Department of Clinical Pharmacy

College of Pharmacy

The University of Tennessee Health Science Center, Memphis, TN, USA

https://academic.uthsc.edu/faculty/facepage.php?netID=claizure&personnel_id=107422

Dr. Laizure’s research interests are in Pharmacogenomics of CNS disorders, Applied Pharmacokinetics, Therapeutic Drug Monitoring, Drug Interactions, Pathophysiology of drug addiction, Alcohol addiction, Therapeutics

Adebowale Adebiyi, Ph.D.

Associate Professor

Department of Physiology

The University of Tennessee Health Science Center, Memphis, TN, USA

http://www.uthsc.edu/physiology/faculty/aadebiyi.php

Dr. Adebiyi’s current research focuses primarily on the physiology and pathophysiology of renal hemodynamics. We utilize an integrative approach, including cell and molecular biology, physiology, and pharmacology techniques to investigate regulatory proteins, ion channels, and GPCRs that control renal vascular and glomerular functions. Current projects in the lab include:

              1. Control of renal microcirculation in adults and neonates.

              2. Mechanisms of altered microvascular function in acute kidney injury.

              3. Ca2+ signaling in glomerular mesangial cells.

             Charles Ryan Yates

            Professor

            Department of Ophthalmology

            College of Medicine

            University of Tennessee Health Science Center, Memphis, TN, USA

Frank Park, Ph.D.

Associate Professor

Department of Pharmaceutical Sciences

College of Pharmacy

The University of Tennessee Health Science Center, Memphis, TN, USA

https://academic.uthsc.edu/faculty/fpark.html

Dr. Park’s lab focuses on the role of Activator of G-protein Signaling, a family of accessory proteins, in renal epithelial cell repair. Upon injury to the kidney by biological insults (eg. ischemia-reperfusion injury or chemicals) or genetic damage, the renal epithelial cells undergo a well orchestrated set of steps to initiate repair of the damaged cells. Due to the importance of G-proteins in this process, our lab has identified novel accessory proteins that can control the activation/inactivation of specific G-protein subunits, specifically AGS3 or GPSM1, to mediate this reparative response in mouse models of renal injury.

Vítor Fernandes, Ph.D.

Biomedical Scientist

Intercellular signaling in cardiovascular development and disease group

Spanish National Center for Cardiovascular Research, Madrid, Spain.

Dr. Fernandes’s recent research: Role of endogenous hydrogen sulfide in nerve-evoked relaxation of pig terminal bronchioles. Impaired Excitatory Neurotransmission in the Urinary Bladder from the Obese Zucker Rat: Role of Cannabinoid Receptors.

Ana Sofia Fernandes Ribeiro, Ph.D.

Associate professor and member of the research commitee

Health Sciences Department - San Juan de Dios School of Nursing and Physical Therapy

Comillas Pontifical University, Madrid, Spain.

             David C. Forbes, Ph.D.

             Professor, Chairman

            Department of Chemistry

            University of South Alabama, AL, USA

             http://www.usouthal.edu/colleges/artsandsci/chemistry/davidcforbes/

Dr. Forbes’s research lies primarily in the area of synthetic organic chemistry. A large component is dedicated toward the development of new methods involving the stereoselective construction of medicinally important compounds. Our research activities are in the area of asymmetric catalysis and synthetic methodology. There is a heavy emphasis toward the development of new methods in the stereoselective synthesis of organic compounds. In terms of the significance and importance of our research efforts, each project's long-term goal is toward the production of chiral molecules of high biological and medicinal importance. Our research program is a blend of both applied and basic research. The capstone experience is focused on chirality.

Xiong-wen Chen, Ph.D.

Associate Professor (with tenure)

Department of Physiology and Cardiovascular Research Center

Temple University School of Medicine, FL, USA

https://medicine.temple.edu/xiongwen-chen

Dr. Chen’s research interests are 1- Ca2+ regulation of gene expression, mitochondria and energy production, protein synthesis and degradation, molecular trafficking and localization, myocyte proliferation and maturation in normal and diseased hearts. 2- The role of smooth muscle cell Ca2+ signaling in hypertension and atherosclerosis. We are using a transgenic mouse model with increased Ca2+ influx into smooth muscle cells for this study. 3- The roles of EPAC and PKI/PKA in heart disease development: we are trying to unveil novel aspects of cAMP signaling by studying the balances between EPAC and PKA, and between PKI and PKA, in cardiac physiology and pathology. Based on the mechanistic study, we will perform translational studies using AAV vectors to overexpress PKI in stressed hearts to ameliorate heart disease development.

      Lin Liu, Ph.D.

Regents Professor of Physiological Sciences

Lundberg-Kienlen Endowed Chair in Biomedical Research

Director, Oklahoma Center for Respiratory and Infectious Diseases

Director, Interdisciplinary Program in Regenerative Medicine at OSU

Director, Lundberg-Kienlen Lung Biology and Toxicology Laboratory

Oklahoma State University, OK, USA

https://ocrid.okstate.edu/center-investigators

Dr. Liu’s research focuses on:Influenza and bacterial infections with a focus on host-pathogen interactions, pathogenesis of pulmonary diseases (IPF, COPD, ARDS and BPD) with a focus on microRNAs and lncRNAs, and stem cell-based therapy with a focus on iPSCs and MSCs..

Shamil D. Akhmedov, M.D., Ph.D.

Professor

Deputy Director for Innovation and Strategic Development

Tomsk National Research Medical Center of the Russian Academy of Sciences

5 Kooperativny Street, Tomsk, 634050, Russia

http://www.tnimc.ru/en/structure/cardiology-research-institute/

V.Samuel Gnana Prakash, Ph.D.

Professor & Head

Department Of Marine Science

Manonmaniam Sundaranar University, India

https://api.skydesk.in/v14/Default.aspx?dlink=https://s4.sathyainfo.com/s/511cf9c4c864444/img

 

 

 

Academic Events hosted/sponsored by

The Laboratory for Cardiovascular Physiology and Pharmacology

Southwest University

 

 

August 2018

Drs. Ana Sofia Fernandes Ribeiro and Vítor Fernandes are working and instructing students in the laboratory.

 

  

 

July 21-31, 2018

Summer classes for selected students in their 4th and 3rd year

Lecture speakers

1.      Thomas Krieg, MD

Honorary Consultant Physician, Acute Medicine, Addenbrooke’s Hospital, Cambridge

University Lecturer, Department of Medicine, University of Cambridge

             Associate Member Gonville and Caius College, Cambridge, London, UK

   

1.      Ana Sofia Fernandes Ribeiro, Ph.D.

Associate professor and member of the research commitee

Health Sciences Department - San Juan de Dios School of Nursing and Physical Therapy

Comillas Pontifical University, Madrid, Spain.

 

2.      Vitor Samuel Leite Fernandes, Ph.D

Biomedical Scientist

Intercellular signaling in cardiovascular development and disease group

Spanish National Center for Cardiovascular Research, Madrid, Spain.

 

 

 

 

 

1.      Frank Park, Ph.D.

Associate Professor

College of Pharmacy

The University of Tennessee Health Science Center, Memphis, TN, USA

 

 

July 27, 2018

Roundtable discussion of international PharmD and graduate study

          

          

          

          

July 26, 2018

Meeting and discussion between the Deans of the College of Pharmaceutical Sciences at Southwest University and the Dean and Department Chair of the College of Pharmacy at the University of Tennessee Health Science Center Memphis.