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李春梅
发布时间2013-08-06 15:50:45     作者:    浏览次数: 次

1、个人概况

李春梅,女,198410月出生,汉族,四川自贡人。中共党员,理学博士,副教授,硕士生导师,主要承担本科生《药物分析学》及《药学专业文献检索》课程。

研究领域:化学生物传感、药物分析、肿瘤成像与治疗。主要开展多功能荧光纳米探针的构建及其在疾病标志物检测、癌细胞成像分析、药物输送及治疗、病毒感染的预防与治疗等方面的研究工作,目前已在国际学术期刊上发表SCI论文50余篇,论文他引1470余次,以第一作者及通讯作者在Adv Funct MaterBiomaterialsAnal Chem等刊物发表SCI论文18篇,参与国际专著《Aptamers Selected by Cell-SELEX for Theranostics》的编写。

2、教育及工作经历:

l   2016/06-至今:西南大学 药学院, 教师

l   2014/03-2016/03,西南大学,生物学博士后流动站,师资博士后

l   2011/09-2013/03,美国University of Florida(佛罗里达大学)化学系、生物/纳米交叉研究中心,纳米生物分析,联合培养博士

l   2009/09-2013/12,西南大学,分析化学,博士

l   2007/09-2009/06,西南大学,药物分析学,硕士(直博)

l   2003/09-2007/06,西南大学,应用化学,学士

3.主持研究的主要科研项目:

[1]  中央高校基本业务费人才团队项目(优青),生物传感与纳米医药(No. XDJK2020TY001), 2020/012022/12

[2]  国家自然科学基金(青年科学基金项目),细胞膜成像探针的构建及对病毒-细胞膜结合过程的实时监测(No. 21705131), 2018/01/012020/12/31

[3]  中央高校基本业务费一般项目,基于双荧光能量转移构建的肿瘤诊疗一体化纳米探针及其诊疗研究(No. XDJK2018C088),2018/042020/12

[4]  重庆市基础科学与前沿技术研究专项项目,基于细胞膜暗场光散射成像研究细胞凋亡过程(cstc2017jcyjAX0167),2017/07/012020/06/30

[5]  中国博士后科学基金面上资助(一等),基于细胞表面纳米传感器实时监测病毒早期侵染过程(No. 2015M570760),2015/052016/03

[6]  重庆市博士后科研项目特别资助(一等),生物功能化金纳米探针的构建及其广谱抗病毒研究(No. xm2014001),2014/092016/02

[7]  中央高校基本业务费一般项目,细胞表面纳米传感器的构建及病毒侵染早期监测(No. XDJK2015C160),2015/052016/12

[8]  西南大学博士基金/引进人才计划项目,基于细胞表面荧光成像研究病毒/细胞膜结合过程(No. SWU116058),2016/102018/09

[9]  化学生物传感与计量学国家重点实验室(湖南大学)2016年开放课题,基于量子点与金纳米粒子的荧光能量转移监测病毒早期侵染过程(No. 2016003),2017/042019/03

4.主要代表论文:

[1]     Wang, J. R.; Xia, C.; Yang, L.; Li, Y. F.; Li, C. M.*; Huang, C. Z.*, DNA nanofirecrackers assembled through hybridization chain reaction for ultrasensitive SERS immunoassay of prostate specific antigen. Anal. Chem. 2020, 92 (5), 4046-4052.

[2]     Cheng, Y. Y.; Xie, Y. F.; Li, C. M.*; Li, Y. F.; Huang, C. Z.*, Förster resonance energy transfer-based soft nanoballs for specific and amplified detection of microRNAs. Anal. Chem. 2019, 91 (17), 11023-11029.

[3]     Chai, S. Q.; Lv, W. Y.; He, J. H.; Li, C. H.; Li, Y. F.; Li, C. M.*; Huang, C. Z.*, Dual energy transfer-based fluorescent nanoprobe for imaging miR-21 in nonalcoholic fatty liver cells with low background. Anal. Chem. 2019, 91 (10), 6761-6768.

[4]     He, L.; Li, Y.; Wu, Q.; Wang, D. M.; Li, C. M.*; Huang, C. Z.; Li, Y. F.*, Ru(III)-based metal–organic gels: intrinsic horseradish and NADH peroxidase-mimicking nanozyme. ACS Appl. Mater. Inter 2019, 11 (32), 29158-29166.

[5]     Chai, S. Q.; He, J. H.; Zhan, L.; Li, Y. F.; Li, C. M.*; Huang, C. Z.*, Dy(III)-induced aggregation emission quenching effect of single-layered graphene quantum dots for selective detection of phosphate in the artificial wetlands. Talanta 2019, 196, 100-108.

[6]     Liu, M. L.; Chen, B. B.; He, J. H.; Li, C. M.*; Li, Y. F.; Huang, C. Z.*, Anthrax biomarker: An ultrasensitive fluorescent ratiometry of dipicolinic acid by using terbium(III)-modified carbon dots. Talanta 2019, 191, 443-448.

[7]     Cheng, Y. Y.; Li, C. M.*; Mu, R. Z.; Li, Y. F.; Xing, T. T.; Chen, B. B.; Huang, C. Z.*, Dynamically long-term imaging of cellular RNA by fluorescent carbon dots with surface isoquinoline moieties and amines. Anal. Chem. 2018, 90 (19), 11358-11365.

[8]     Yang, T.; Li, C. M.*; He, J. H.; Chen, B.; Li, Y. F.; Huang, C. Z.*, Ratiometrically fluorescent dlectrospun nanofibrous film as a Cu2+-mediated solid-phase immunoassay platform for biomarkers. Anal. Chem. 2018, 90 (16), 9966-9974.

[9]     Chen, B. B.; Liu, M. L.; Zhan, L.; Li, C. M.*; Huang, C. Z.*, Terbium(III) modified fluorescent carbon dots for highly selective and sensitive ratiometry of stringent. Anal. Chem. 2018, 90 (6), 4003-4009.

[10]  He, L.; Jiang, Z. W.; Li, W.; Li, C. M.*; Huang, C. Z.; Li, Y. F.*, In situ synthesis of gold nanoparticles/metal–organic gels hybrids with excellent peroxidase-like activity for sensitive chemiluminescence detection of organophosphorus pesticides. ACS Appl. Mater. Inter 2018, 10 (34), 28868-28876.

[11]  Zheng, L. L.; Li, C. M.*; Zhen, S. J.; Li, Y. F.; Huang, C. Z.*, A dynamic cell entry pathway of respiratory syncytial virus revealed by tracking the quantum dot-labeled single virus. Nanoscale 2017, 9 (23), 7880-7887.

[12]  Zhan, L.; Wu, W. B.; Li, C. M.*; Huang, C. Z.*, Magnetic bead-based sandwich immunoassay for viral pathogen detection by employing gold nanoparticle as carrier. Journal of Analysis and Testing 2017, 1 (4), 298-305.

[13]  Li, C. M.; Zheng, L. L.; Yang, X. X.; Wan, X. Y.; Wu, W. B.; Zhen, S. J.; Li, Y. F.; Luo, L. F.; Huang, C. Z. * DNA-AuNP networks on cell membranes as a protective barrier to inhibit viral attachment, entry and budding. Biomaterials. 2016, 77, 216-226.

[14]  Li, C. M.; Zhan, L.; Zheng, L. L.; Li, Y. F.; Huang, C. Z.* Magnetic nanoparticle-based aptasensor for selective and sensitive determination of lysozyme with strongly scattering silver nanoparticles. Analyst. 2016, 141, 3020-3026.

[15]  Li, C. M.; Chen, T.; Ocsoy, I.; Zhu, G. Z.; Yasun, E.; You, M. X.; Wu, C. C.; Zheng, J.;  Song, E. Q.; Huang, C. Z.*; Tan, W. H. * Gold-Coated Fe3O4 Nanoroses with Five Unique Functions for Cancer Cell Targeting, Imaging and Therapy. Adv. Funct. Mater.  2014, 24, 1772-1780.

[16]   Li, C. M.; Zhen, S. J.; Wang, J.; Li, Y. F.; Huang, C. Z.* A gold nanoparticles-based colorimetric assay for alkaline phosphatase detection with tunable dynamic range. Biosens. Bioelectron. 2013, 43, 366-371.

[17]  Li, C. M.; Li, Y. F.; Wang, J.; Huang, C. Z.* Optical investigations on ATP-induced aggregation of positive-charged gold nanoparticles. Talanta. 2010, 81, 1339-1345.

[18]  Li, C. M.; Li, Y. F.; Huang, C. Z.*; Long, Y. F. A visual test paper for extremely strong concentrated acidity with a new synthesized isoindole reagent. Talanta.  2009, 78, 1173-1176.

5. 联系方式:

电话:023-68254059

电子邮箱:licm1024@swu.edu.cn

通信地址:重庆市北碚区天生路2号,西南大学药学院,400715