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左华
发布时间2013-09-01 08:01:36     作者:    浏览次数: 次

左华,女,副教授,博士,硕士生导师,2008年毕业于韩国国立昌原大学(Changwon National University),2014-2015年在美国普渡大学Chengde Mao实验室访学。目前招收药物化学、药物分析方向的硕士研究生。

主要研究领域及教学内容:主要研究方向为药物及中间体合成;DNA的自组装、以DNA为模板的有机合成;荧光有机小分子探针的合成及应用。目前研究领域为Smiles重排用于C-C键、C-N键和C-S键的形成,以及黄樟素氧化物的衍生物的合成研究。近几年主要从事:1Smiles 重排在有机合成中的应用,寻找并发现具有潜在生物活性的小分子。利用该重排反应,合成了二苯胺、吡啶基苯胺、苯并噻嗪酮、苯并噁嗪酮、黄樟素氧化物的氨基衍生物、吡啶噁嗪酮;合成了香豆素类、色满类、苯并呋喃等化合物。2)通过T-junction作用研究DNA自组装成纳米笼;以DNA为模板探索有机酰化等反应。3)合成罗丹明衍生物的有机小分子探针及应用于生物检测承担研究生和本科的波谱解析、《有机化学》、《药物合成》、《药学英语》、《制药工艺学》等专业课程。

近几年发表论文:

(1) Zuo, H.*; Wu, S.; Li, M.; Li, Y.; Jiang, W.; Mao, C*. A case study of the likes and dislikes of DNA and RNA in self-assembly. Angew. Chem. Int. Edit. 2015, 54, 15118. (Selected as inside cover and hot paper)

(2) Xia, S.; Xiao, S.-Y.; Hong, Q.-Q.; Zou, J.-R.; Yang, S.; Zhang, M.-X.; Zuo, H*. A novel sensitive fluorescent turn-on probe for rapid detection of Al3+ and bioimaging. RSC Adv. 2015, 5, 5244.

(3) Tan, J.-L.; Zhang, M.-X.; Zhang, F.; Yang, T.-T.; Liu, Y.; Li, Z.-B.; Zuo, H*. A novel ‘‘off–on’’ colorimetric and fluorescent rhodamine-based pH chemosensor for extreme acidity. Spectrochim Acta A Mol Biomol Spectrosc. 2015, 140, 489.

(4) Xia, S.; Liu, J.-Q.; Wang, X.-H.; Tian, Y.; Wang, Y.; Wang , J.-H.; Fang, L.; Zuo, H. * Smiles rearrangement for the synthesis of 4,7-disubstituted-2H-benzo[b][1,4]-oxazin-3(4H)-ones and their in vitro evaluation as platelet aggregation inhibitors, Bioorg. Med. Chem. Lett, 2014, 24 (6), 147.

(5) Liu, C.; Tan, J.-L.; Xiao, S.-Y.; Liao, J.-F.; Zou, G.-R.; Ai, X.-X.; Chen, J.-B.; Xiang, Y.; Yang, Q.; Zuo, H.* 1,4-Benzoxazine-3(4H)-ones as potent inhibitors of platelet aggregation: design, synthesis and structure–activity relations. Chem. Pharm. Bull. 2014, 62, 915.

(6) Xia, S.; Wang, X.-H.; Liu, J.-Q.; Liu, C.; Chen, J.-B.; Zuo, H. *; Xie, Y.-S.; Dong W.-L.; Shin, D.-S. A facile protocol for the synthesis of benzofuran derivatives by the reaction of o-hydroxy aryl ketone, amine and chloroacetyl chloride. Bull. Korean Chem. Soc, 2014, 35 (6), 1743.

(7) Xia, S.; Wang, L.-Y.; Zuo, H. *; Li, Z.-B.; Smiles rearrangement in synthetic chemistry. Cur. Org. Syn. 2013, 10 (6), 935.

(8) Xie, Y.-S.; Vijaykumar, B. V. D.; Jang, K.; Shin, H.-H.; Zuo, H.; Shin, D.-S. One-pot conversion of phenols to anilines via Smiles rearrangement. Tetrahedron Lett 2013, 54, 5151.

(9) Xia, S.; Wang, L.-Y.; Sun, H.-Z.; Yue, H.; Wang, X.-H.; Tan, J.-L.; Wang, Y.; Hou, D.; He, X.-Y.; Mun, K.-C.; Kumar, B.P.; Zuo, H. *; Shin, D.-S. Synthesis of N-azaaryl anilines: an efficient protocol via Smiles rearrangement. Bull. Korean Chem. Soc. 2013, 34(2), 394.

(10) Tian, X.; Wang, L.-Y.; Xia, S.; Li, Z.-B.; Liu, X.-H.; Yuan, Y.; Fang, L.; Zuo, H.*, Synthesis of 2H-benzo[b][1,4] oxazin-3(4H)-one derivatives as platelet aggregation inhibitors. Bioorg. Med. Chem. Lett. 2012, 22 (1), 204.

(11) Xia, S.; Wang, L.-Y.; Sun, H.-Z.; Yue, H.; Wang, X.-H.; Tan, J.-L.; Wang,Y.; Hou, D.; He, X.-Y.; Mun, K.-C.; Kumar, B.P.; Zuo, H. *; Shin, D.-S, Synthesis of N-azaaryl anilines: an efficient protocol via Smiles rearrangement, Bull. Korean Chem. Soc. 2013, 34(2), 394.

(12) Wang, L.-Y.; Wang, X.-H.; Tan, J.-L.; Xia, S.; Sun, H.-Z.; Shi, J.-W.; Jiang, M.-D.; Fang, L.; Zuo, H.*; Dupati, G.; Jang, K.; Shin, D.-S, New safrole oxide derivatives: synthesis and in vitro antiproliferative activities on human lung cancer cells, Bull. Korean Chem. Soc. 2012, 33(11), 3571.

(13) Meng, L.-J.; Vijaykumar, B.V.D.; Zuo, H.; Li, Z.-B.; Dupati, G.; Jang, K.; Shin, D.-S, Stereoselective synthesis of (3S,4R)- and (3R,4S)-4-(N-substituted-amino)-2,2-dimethyl- 6- nitrochroman-3-ols via the microwave assisted regioselective ring opening of epoxides in the presence of neutral alumina, Tetrahedron Asy. 2012, 23, 1029.

(14) Zuo, H.; Li, Z.-B.; Zhao, B.-X.; Miao, J.-Y.; Meng, L.-J.; Jang, K.; Ahn, C.; Lee, D.-H.; Shin, D.-S. Highly efficient microwave-assisted aminolysis of epoxides in water. Bull. Korean Chem. Soc. 2011, 32, 2965. 

(15) Yang, H.; Fang, L.; Li, Z.-B.; Ren, F.-K.; Wang, L.-Y.; Tian, X.; Shin, D.-S.; Zuo, H.* Synthesis and in vitro antimicrobial activity of benzo[b][1,4] thiazin- 3(4H)-ones via Smiles rearrangement, Med. Chem. Res. 2011, 20 (1), 93.

(16) Fang, L.; Zuo, H.*; Li, Z.-B.; He, X.-Y.; Wang, L.-Y.; Tian, X.; Zhao, B.-X.; Miao, J.-Y.; Shin, D.-S, Synthesis of benzo[b][1,4]oxazin-3(4H)-ones via Smiles rearrangement for antimicrobial activity, Med. Chem. Res. 2011, 20, 670.

(17) Tian, X.; Wu, R.-M.; Liu, G.; Li, Z.-B.; Wei, H.-L.; Yang, H.; Shin, D.-S.; Wang, L.-Y.; Zuo, H.*,Smiles rearrangement for the synthesis of diarylamines. ARKIVOC 2011, x, 118.

(18) Zuo, H.; Li, Z.-B.; Zhao, B.-X.; Miao, J.-Y.; Meng, L.-J.; Jang, K.; Ahn, C.; Lee, D.-H.; Shin, D.-S., Highly efficient microwave-assisted aminolysis of epoxides in water, Bull. Korean Chem. Soc. 2011, 32, 2965. 

(19) Yang, H.; Li, Z.-B.; Shin, D.-S.; Wang, L.-Y.; Zhou, J.-Z.; Qiao, H.-B.; Tian, X.; Ma, X.-Y.; Zuo, H.* A facile C-N bond formation: one-pot reaction of phenols and amines via Smiles rearrangement. SYNLETT 2010, 3, 483. 

(20) Zuo, H.; Li, Z.-B.; Ren, F.-K.; J. R. Falck; Meng, L.; Ahn, C.; Shin, D.-S. Microwave- assisted one-pot synthesis of benzo[b][1,4]thiazin-3(4H)-ones via Smiles rearrangement. Tetrahedron 2008, 64, 9669. 

(21) Zuo, H.; Meng, L.; Ghate, M.; Hwang, K.-H.; Cho, Y.-K.; Chandrasekhar, S.; Reddy, C. R.; Shin, D.-S. Microwave-assisted one-pot synthesis of benzo[b] [1,4]oxazin-3(4H)-ones via Smiles rearrangement. Tetrahedron Lett. 2008, 49, 3827.

(22)  Zuo, H.; Jose, G.; Li, Z.-B.; Moon, B.-H.; Shin, D-S. Microwave-assisted synthesis of fluorinated coumarino sulfonamides. ARKIVOC, 2008, ii, 183.

(23)  Zuo, H.; Kam, K.-H.; Kwon, H. -J.; Meng, L. -J.; Ahn, C. -J.; Won, T. -J.; Kim,   T. -H.; Reddy, Ch. R.; Chandrasekhar, S.; Shin, D. -S. Microwave-assisted  synthesis of 2H-benzo[b][1,4]oxazin-3(4H)-ones and 1H-pyrido[2,3-b] [1,4] oxazin-2(3H)-ones via Smiles rearrangement. Bull. Korean Chem. Soc. 2008, 29, 1379. 

授权的专利:

1. 左华,杨浩,李逐波 等,N-芳烷基苯胺类化合物的合成方法,2012年12月授权,中国发明专利,ZL 200910104093.1.

2. 李逐波,任方奎,左华 等,低刺激性大蒜素衍生物及其合成方法和应用,2011 7 月授权,中国发明专利,ZL 2008 10070362.2

3. 李逐波,廖丹丹,赵晨光,左华 等,苦参碱磺酸钠及其制备方法,2011 7 月授权,中国发明专利,ZL 200910104092.7

联系方式:

电话: 15923206991  023-68251503   传真:023-68251225 

电子邮箱: zuohua@swu.edu.cn