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药物分析教研室
发布时间2014-01-12 23:30:03     作者:    浏览次数: 次

 

药物分析教研室

药物分析教研室成员包括黄承志、付志锋、陈敏、杨晓明、刘忠德、宋尔群、王健、刘慧、肖国君。其中教授4人,副教授3人,讲师2人;博士生导师1人,硕士生导师6人,成员中8人获得博士学位,6人具有海外留学经历。

药物分析教研室现有实验室面积300m2左右,拥有高效液相色谱仪、荧光分光光度计、紫外可见分光光度计、酶标仪、化学发光仪、旋转蒸发仪、离心机等多台仪器,能够充分保证化学及生物药物分析、体内药物与疾病标志物分析、天然药物分析等方向的研究。

本教研室主要承担本科药学、制药工程、中药学等专业的《药物分析》、《分析化学》、《仪器分析》、《天然产物分析》等课程的理论及实验教学,以及研究生各专业《仪器分析》、《药学进展》等课程。

本教研室成员紧紧围绕药物质量控制,分别从事化学及生物药物分析、体内药物与疾病标志物分析、天然药物分析等方向的研究。近年来,本教研室成员在纳米材料在疾病标志物检测与成像示踪等方面开展了一系列探索性的研究。以疾病标志物和肿瘤细胞为研究对象,合成了数种新型的纳米信号探针,实现了疾病标志物检测过程中的信号放大。此外,构建了新型纳米生物传感界面,研制了多种高性能的免疫传感器;配合高通量、高速度的流动分析技术、微流控芯片技术和传感器阵列技术,提高了疾病标志物检测过程中的所获信息的深度与广度;合成了各类新型发光纳米材料,用于肿瘤细胞的标记/光学成像与分选。

 

 

药物分析教研室近5年部分基金项目

 

序号

项目名称及编号

项目来源

负责人

项目起止时间

候选人作为完成人的顺序

1

量子点标记技术研究病毒侵染过程及宿主应答

项目编号:2011CB933604

国家973项目

黄承志

2011.01-2015.12

1

2

长程共振能量转移及其在生物医药分析中的应用

项目编号:21035005

国家自然科学基金重点项目

黄承志

2011.01-2014.12

1

3

典型纳米材料的毒性研究

重庆市自然科学基金重点项目

黄承志

2012.05-2015.04

1

4

 

基于时间分辨化学发光的多元免疫分析

项目编号:21175111

国家自然科学基金

付志锋

2012.01-2015.12

1

5

电致化学发光多组分免疫传感器阵列

项目编号:20805036

国家自然科学基金

付志锋

2009.01-2011.12

1

6

藏药巴朱抗肿瘤活性成分快速发现及作用机制研究

项目编号:81102894

国家自然科学基金

陈敏

2012.01-2014.12

1

7

甘薯花色素苷和β-胡萝卜素植物生物反应器研制

项目编号:2011AA100607

国家863项目子课题

陈敏

2011.01-2015.12

1

8

红景天代谢工程育种关键技术研究

项目编号:2011BAI13B06

国家科技支撑计划子课题

陈敏

2011.01-2014.12

1

9

 

胰腺癌细胞对吉西他滨产生抗药性的分子机制研究              

项目编号:31100981

国家自然科学基金

杨晓明

2012.01-2014.12

1

10

基于荧光—磁性智能探针灵敏快速检测肿瘤标志物的多组分免疫分析方法研究

项目编号:21005064

国家自然科学基金

宋尔群

2011.01-2013.12

1

11

手性光学活性金属纳米材料的制备及手性分离与传感应用

项目编号:21205096

国家自然科学基金

刘忠德

2013.01-2015.12

1

 

5年代表性学术论文:

1Wang, J.; Zhu, G.; You, M.; Song, E.; Shukoor, M. I.; Zhang, K.; Altman, M. O. D.; Chen, Y.; Zhu, Z.; Huang, C. Z.; Tan, W. Assembly of Aptamer Switch Probes and Photosensitizer on Gold Nanorods for Targeted Photothermal and Photodynamic Cancer Therapy. ACS Nano 2012, 6, 5070-5077. (IF=10.774)

2Zhang, L.; Chen, H.; Wang, J.; Li, Y. F.; Wang, J.; Sang, Y.; Xiao, S. J.; Zhan, L.; Huang, C. Z. Tetrakis(4-Sulfonatophenyl)Porphyrin-Directed Assembly of Gold Nanocrystals: Tailoring the Plasmon Coupling through Controllable Gap Distances. Small 2010, 6, 2001-2009. (IF=8.349)

3Wang, J.; You, M.; Zhu, G.; Shukoor, M. I.; Chen, Z.; Zhao, Z.; Altman, M. B.; Yuan, Q.; Zhu, Z.; Chen, Y.; Huang, C. Z.; Tan, W. Photosensitizer-Gold Nanorod Composite for Targeted Multimodal Therapy. Small 2013, in press. (IF=8.349)

4Chen, L. Q.; Xiao, S. J.; Hu, P. P.; Peng, L.; Ma, J.; Luo, L. F.; Li, Y. F.; Huang, C. Z. Aptamer-Mediated Nanoparticle-Based Protein Labeling Platform for Intracellular Imaging and Tracking Endocytosis Dynamics. Anal. Chem. 2012, 84, 3099-3110. (IF=5.874)

5Liu, J.-H.; Wang, C.; Jiang, Y.; Hu, Y.; Li, J.; Yang, S.; Li, Y.; Yang, R.; Tan, W.; Huang, C. Z. Graphene Signal Amplification for Sensitive and Real-Time Fluorescence Anisotropy Detection of Small Molecule. Anal. Chem. 2013, 85, 1424-1430. (IF=5.874)

6Xiao, S. J.; Hu, P. P.; Wu, X. D.; Zou, Y. L.; Chen, L. Q.; Peng, L.; Ling, J.; Zhen, S. J.; Zhan, L.; Li, Y. F.; Huang, C. Z. Sensitive Discrimination and Detection of Prion Disease-Associated Isoform with a Dual-Aptamer Strategy by Developing a Sandwich Structure of Magnetic Microparticles and Quantum Dots. Anal. Chem. 2010, 82, 9736-9742. (IF=5.874)

7Zhen, S. J.; Chen, L. Q.; Xiao, S. J.; Li, Y. F.; Hu, P. P.; Zhan, L.; Peng, L.; Song, E. Q.; Huang, C. Z. Carbon Nanotubes as a Low Background Signal Platform for a Molecular Aptamer Beacon on the Basis of Long-Range Resonance Energy Transfer. Anal. Chem. 2010, 82, 8432-8437. (IF=5.874)

8Hu, P. P.; Chen, L. Q.; Liu, C.; Zhen, S. J.; Xiao, S. J.; Peng, L.; Li, Y. F.; Huang, C. Z. Ultra-Sensitive Detection of Prion Protein with a Long Range Resonance Energy Transfer Strategy. Chem. Commun. 2010, 46, 8285-8287. (IF=6.169)

9Liu, Y.; Ling, J.; Huang, C. Z. Individually Color-coded Plasmonic Nanoparticles for RGB analysis. Chem. Commun. 2011, 47, 8121-8123. (IF=6.169)

10Long, Y. J.; Li, Y. F.; Liu, Y.; Zheng, J. J.; Tang, J.; Huang, C. Z. Visual Observation of the Mercury-stimulated Peroxidase Mimetic Activity of Gold Nanoparticles. Chem. Commun. 2011, 47, 11939-11941. (IF=6.169)

11Qi, W. J.; Wu, D.; Ling, J.; Huang, C. Z. Visual and Light Scattering Spectrometric Detections of Melamine with Polythymine-stabilized Gold Nanoparticles through Specific Triple Hydrogen-bonding Recognition. Chem. Commun. 2010, 46, 4893-4895. (IF=6.169)

12Wang, Y.; Li, Y. F.; Wang, J.; Sang, Y.; Huang, C. Z. End-to-End Assembly of Gold Nanorods by Means of Oligonucleotide-Mercury(II) Molecular Recognition. Chem. Commun. 2010, 46, 1332-1334. (IF=6.169)

13Yu, Y.; Liu, Y.; Zhen, S. J.; Huang, C. Z. A Graphene Oxide Enhanced Fluorescence Anisotropy Strategy for DNAzyme-Based Assay of Metal Ions. Chem. Commun. 2013, 49, 1942-1944. (IF=6.169)

14Zhang, L.; Zhen, S. J.; Sang, Y.; Li, J. Y.; Wang, Y.; Zhan, L.; Peng, L.; Wang, J.; Li, Y. F.; Huang, C. Z. Controllable Preparation of Metal Nanoparticle/Carbon Nanotube Hybrids as Efficient Dark Field Light Scattering Agents for Cell Imaging. Chem. Commun. 2010, 46, 4303-4305. (IF=6.169)

15Zhang, Y.; Liu, Y.; Zhen, S. J.; Huang, C. Z. Graphene Oxide as an Efficient signal-to-background Enhancer for DNA Detection with a Long Range Resonance Energy Transfer Strategy. Chem. Commun. 2011, 47, 11718-11720. (IF=6.169)

16Zhao, H. X.; Liu, L. Q.; Liu, Z. D.; Wang, Y.; Zhao, X. J.; Huang, C. Z. Highly Selective Detection of Phosphate in Very Complicated Matrixes with an off–on Fluorescent Probe of Europium-adjusted Carbon Dots. Chem. Commun. 2011, 47, 2604-2606. (IF=6.169)

17Zhen, S. J.; Guo, F. L.; Chen, L. Q.; Li, Y. F.; Zhang, Q.; Huang, C. Z. Visual Detection of Cobalt(II) Ion in vitro and Tissue with a New Type of Leaf-like Molecular Microcrystal. Chem. Commun. 2011, 47, 2562-2564. (IF=6.169)

18Zhao, X. J.; Huang, C. Z. Small Organic Molecules as Fluorescent Probes for Nucleotides and Their Derivatives. Trac-Trends Anal. Chem. 2010, 29, 354-367.

19Li, C. M.; Zhen, S. J.; Wang, J.; Li, Y. F.; Huang, C. Z. A Gold Nanoparticles-based Colorimetric Assay for Alkaline Phosphatase Detection with Tunable Dynamic Range. Biosens. Bioelectron. 2013, 43, 366-371. (IF=5.602)

20Wang, J.; Zhang, P.; Li, C. M.; Li, Y. F.; Huang, C. Z. A Highly Selective and Colorimetric Assay of Lysine by Molecular-Driven Gold Nanorods Assembly. Biosens. Bioelectron. 2012, 34, 197-201. (IF=5.602)

21Zhao, X. J.; Huang, C. Z. Selective Fluorometric Detection of Pyrophosphate and Stringent Alarmone with Copper(II)-2,6-bis(2-benzimidazolyl)pyridine Complex. Biosens. Bioelectron. 2011, 30, 282-286. (IF=5.602)

22ZF Fu, GC Shao, J Wang, DL Lu, WJ Wang, and YH Lin*. Microfabricated renewable beads-trapping/releasing flow cell for rapid antigen−antibody reaction in chemiluminescent immunoassay, Anal. Chem., 2011, 83: 2685. (IF=5.874)   

23CF Li, ZF Fu*, ZY Li, ZX Wang, W Wei. Cross-talk-free multiplexed immunoassay using a disposable electrochemiluminescent immunosensor array coupled with a non-array detector. Biosens. Bioelectron., 2011, 27: 141-147. (IF=5.602) 

24ZY Li, YH Wang, WJ Kong, CF Li, ZX Wang, ZF Fu*, Highly sensitive near-simultaneous assay of multiple ‘‘lean meat agent’’ residues in swine urine using a disposable electrochemiluminescent immunosensors array, Biosens. Bioelectron., 2013, 39, 311-314. (IF=5.602)   

25Min Chen*, Xiumei Xu, Bing Xu, Panpan Yang, Zhihua Liao, Susan L. Morris-Natschke, Kuo-Hsiung Lee,* and Daofeng Chen.* Neglschisandrins E–F: Two New Lignans and Related Cytotoxic Lignans from Schisandra neglecta. Molecules, 2013, 18, 2297-2306. (IF=1.988)

 

26Min Chen, Nicole Kilgore, Kuo-Hsiung Lee and Daofeng Chen. Rubrisandrins A and B, Lignans and Related Anti-HIV Compounds from Schisandra rubriflora. J. Nat. Prod. 2006, 69:1697-1901. (IF=2.872)

27Xiaoming Yang*, Yao Dou, Shanshan Zhu. Highly sensitive detection of superoxide dismutase based on an immunoassay with surface-enhanced fluorescence. Analyst, 2013, DOI:10.1039/C3AN00471F. (SCI, IF=4.23)

28Xiaoming Yang, Hongchang Li, Zinan Zhou, Wen-Hong Wang, Anping Deng, Ourania Andrisani, and Xiaoqi Liu*. Plk1-mediated phosphorylation of topors regulates P53 stability. J Biol Chem. 2009, 284:18588-18592. (SCI, IF=5.328)

29Xiaoming Yang, Hongchang Li, Shawn Liu, Anping Deng, and Xiaoqi Liu*. CDC2-mediated phosphorylation of CLIP-170 is essential for its inhibition of centrosome reduplication. J Biol Chem. 2009, 284:28775-28782. (SCI, IF=5.328)

30Song, E. Q;* Cheng, D; Song, Y; Jiang, M. D; Yu, J. F; Wang, Y. Y. 2013, A graphene oxide-based FRET sensor for rapid and sensitive detection of matrix metalloproteinase 2 in human serum sample. Biosensors and Bioelectronics(IF=5.602), doi: 10.1016/j.bios.2013.03.030.

31Song, E. Q.; Hu, J.; Wen, C. Y.; Tian, Z. Q.; Yu, X.; Zhang, Z. L.; Shi, Y. B.; Pang, D. W.* 2011, Fluorescent-magnetic-biotargeting multifunctional nanobioprobes for detecting and isolating multiple types of tumor cells. ACS Nano(IF=10.774)  5(2), 761-770.

32Liu, Z. D.; Li, Y. F.; Ling, J.; Huang, C. Z. 2009, A Localized Surface Plasmon Resonance Light-Scattering Assay of Mercury (II) on the Basis of Hg2+-DNA Complex Induced Aggregation of Gold Nanoparticles. Environ. Sci. Technol. (IF=5.2) 43, 5022-5027.

33Liu, Z. D.; Hu, P. P.; Zhao, H. X.; Li, Y. F.; Huang, C. Z. 2011, Carbon nanotube–DNA hybrid used for activity monitoring and inhibitor screening of nuclease. Anal. Chim. Acta. (IF=4.1), 706, 171– 175.

34Liu, Z. D.; Zhao, H. X.; Huang, C. Z. 2012, Obstruction of Photoinduced Electron Transfer from Excited Porphyrin to Graphene Oxide: A Fluorescence Turn-On Sensing Platform for Iron (III) Ions. PLOS ONE, (IF=4.0),7, e50367.