陆军 教授，博士，西南大学药学院药理教研室主任
联系地址E-mail: junlu@swu.edu.cn
教育经历
1988-1992年 四川大学化学系 学士学位
1992-1995年 四川大学化学系 硕士学位
1995-1998年 中科院长春应用化学研究所 博士学位
科研经历
1999-2000年 中科院长春应用化学研究所 助理研究员,
2000-2002年 日本理化学研究所 STA、JSPS博士后
2003-2005年 瑞典卡罗琳斯卡医学院 博士后
2005-2009年 瑞典卡罗琳斯卡医学院 研究员
2009-2013年 瑞典卡罗琳斯卡医学院 助理教授
2013-2016年 瑞典卡罗琳斯卡医学院 高级研究员
2016年6月- 西南大学药学院 教授
2018年3月- 西南大学药学院 药理教研室主任
荣誉奖励和学术兼职
2016.12 重庆市“百人计划”专家
2018.08 重庆市药理学会理事
2019.06 中国生物物理学会自由基生物学与医学专业委员会理事
国际杂志编委
学术编辑： Frontier in Physiology
BioMed Research International
地区编辑：Current Pharmaceutical Biotechnology
教学
英文班药理学、仪器分析 （本科生）
中外主文献研读、高等药理学（研究生）
Molecular Pharmacology （国际研究生）
研究方向
1. 分子药理学：以生物氧化还原体系为靶向的药物药理、毒理、耐药性研究及新药开发（硫氧还蛋白体系、谷胱甘肽体系、硒蛋白、硒代谢、铁代谢、巯基代谢、自由基生物学和医学、氧化还原生物学、细菌耐药机制等）。
2. 合成生物学：微生物菌种基因工程改造、微生物来源药物的研发（可招收专业硕士生）
研究成果
在PNAS、EMBO Molecular Medicine、Cancer Research等刊物上发表60余篇SCI论文，他引6000余次，H-index 33，获2项美国发明专利授权。
可以欢迎有志于新药研发和微生物基因工程的学生、博士后加盟本实验室！
代表性文章 (*通讯作者)：
1. Li J, Cheng P, Li S, Zhao P, Han B, Ren X, Zhong JL, Lloyd MD, Pourzand C, Holmgren A, Lu J*. Selenium Status in Diet Affects Acetaminophen-Induced Hepatotoxicity via Interruption of Redox Environment. Antioxid Redox Signal. 2021, 34(17):1355-1367.
2. Cheng P, Liu H, Li Y,Pi P, Jiang Y, Zang S, Li X, Fu A, Ren X, Xu J, Holmgren A, Lu J*. Inhibition of Thioredoxin Reductase 1 Correlates With Platinum-Based Chemotherapeutic Induced Tissue Injury. Biochem Pharmacol. 2020, 175:113873
3. Dong C, Zhou J, Wang P, Li T, Zhao Y, Ren X, Lu J, Wang J, Holmgren A, Zou L. Topical Therapeutic Efficacy of Ebselen Against Multidrug-Resistant Staphylococcus aureus LT-1 Targeting Thioredoxin Reductase. Front Microbiol.2020, 10, 3016.
4. Lu J*. Therapy Based on the Regulation of Thiol-dependent Redox Systems. (Editorial) Curr Med Chem.2020, 27(12):1876-1877.
5. Ouyang Y, Li J, Peng Y, Huang Z, Ren Q, Lu J*. The Role and Mechanism of Thiol-Dependent Antioxidant System in Bacterial Drug Susceptibility and Resistance. Curr Med Chem. 2020, 27(12):1940-1954
6. Li J, Zuo X, Cheng P, Ren X, Sun S, Xu J, Holmgren A, Lu J*. The production of reactive oxygen species enhanced with the reduction of menadione by active thioredoxin reductase. Metallomics. 2019, 11(9):1490-1497.
7. Ouyang Y, Peng Y, Li J, Holmgren A, Lu J*. Modulation of thiol-dependent redox system by metal ions via thioredoxin and glutaredoxin systems. Metallomics. 2018, 10(2):218-228.
8. Zou L, Lu J*, Wang J, Ren X, Zhang L, Gao Y, Rottenberg ME, Holmgren A*. Synergistic antibacterial effect of silver and ebselen against multidrug-resistant Gram-negative bacterial infections. EMBO Mol Med. 2017, 9(8):1165-1178.
9. Ren X, Zou L, Zhang X, Branco V, Wang J, Carvalho C, Holmgren A, Lu J*. Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System. Antioxid Redox Signal. 2017, 27(13):989-1010
10. Álvarez-Zaldiernas C, Lu J*, Zheng Y, Yang H, Blasi J, Solsona C*, Holmgren A*. Cellular Redox Systems Impact the Aggregation of Cu, Zn Superoxide Dismutase Linked to Familial Amyotrophic Lateral Sclerosis. J Biol Chem., 2016, 291(33):17197-17208.
11. Olivera C, Ren X, Vodnala SK, Lu J, Coppo L, Leepiyasakulchai C, Holmgren A, Kristensson K, Rottenberg M, Nitric oxide protects the integrity of the blood-brain barrier during the infection with Trypanosoma brucei, PLoS Pathog, 2016, 12(2): e1005442.
12. Zhang X, Lu J*, Ren X, Du Y, Zheng Y, Ioannou PV, Holmgren A*, Oxidation of structural cysteine residues in thioredoxin 1 by aromatic arsenicals enhances cancer cell cytotoxicity caused by the inhibition of thioredoxin reductase 1. Free Radic Biol Med. 2015, 89:192-200.
13. Lu J, Holmgren A, The thioredoxin superfamily in oxidative protein folding, Antioxid Redox Signal, 2014, 457-470.
14. Lu J*, Holmgren A*, The thioredoxin antioxidant system. Free Radic Biol Med, 2014, 66: 75-87.
15. Lu J, Vodnala SK, Gustavsson AL, Gustafsson TN, Sjöberg B, Johansson HA, Kumar S, Tjernberg A, Engman L, Rottenberg ME, Holmgren A, Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei, J Biol Chem, 2013, 288(38): 27456-27468.
16. Lu J, Vlamis-Gardikas A, Kandasamy K, Zhao R, Gustafsson TN, Engstrand L, Hoffner S, Engman L, Holmgren A, Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione, FASEB J, 2013, 27(4): 1394-1403.
17. Lu J, Holmgren A, Thioredoxin system in cell death progression, Antioxid Redox Signal, 2012, 17(12): 1738-1747.
18. Zhang X, Zheng YJ, Fried LE, Du Y, Montano SJ, Sohn A, Lefkove B, Holmgren L, Arbiser JL, Holmgren A*, Lu J*, Disruption of mitochondrial thioredoxin system as a cell death mechanism of cationic triphenylmethanes, Free Radical Biology & Medicine, 2011, 50(7): 811-20.
19. Lu J*, Zhong L, Lönn ME, Burk RF, Hill KE, Holmgren A*, Penultimate selenocysteine residue replaced by cysteine in thioredoxin reductase from selenium-deficient rat liver, FASEB J, 2009, 23(8): 2394-2402.
20. Lu J, Holmgren A, Selenoproteins. J Biol Chem, 2009, 284(2): 723-727.
21. Lu J, Berndt C, Holmgren A, Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase. Biochim Biophys Acta, 2009, 1790(11): 1513-1519.
22. Lu J, Chew EH, Holmgren A, Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide, Proc Natl Acad Sci U S A, 2007, 104(30): 12288-12293.
23. Papp LV, Lu J, Holmgren A, Khanna KK, From selenium to selenoproteins: Synthesis, identity and their role in human health, Antioxid. Redox Signal, 2007, 9(7): 775-806.
24. Lu J, Papp LV, Fang J, Rodriguez-Neto S, Zhivotovsky B, Holmgren A, Inhibition of mammalian thioredoxin reductase by some flavonoids: Implications for myricetin and quercetin anticancer activity, Cancer Res, 2006, 66(8): 4410-4418.
授权发明专利：
1. Holmgren A, Lu J, Vlamis-Gardikas A, Zhao R, Kandasamy K, Engman L, Engstrand L, Hoffner S. Bacterial thioredoxin reductase inhibitions and methods for use thereof. U.S. Patent, patent No.: US 2014/0088149 A1. Patent open date：2014.3.27. （美国专利）
2. Holmgren A, Lu J. Composition comprising selenazol or thiazolone derivates and silver and method of treatment therewith. U.S. Patent, patent No.: 10,085,542, Patent open date：2018.8.28（美国专利）
