基本情况
教授，博士生导师，西南大学药学院党委书记。巴渝岐黄学者，重庆市高校中青年骨干教师。重庆市高校中药新药筛选重点实验室主任、西南大学现代中药研究所所长。主要从事中药及民族药（藏药）活性成分与靶点发现、创新药物研发、质量控制研究。先后主持国家自然科学基金、国家重点研发计划子课题、国家重大新药创制子课题、重庆市科技局重点项目、重庆市卫健委重点项目等项目30余项；在Research、Organic Letters、Phytomedicine等国内外学术期刊发表相关研究论文150余篇；授权发明专利12项。兼任中华中医药学会中药实验药理分会常务委员、世界中医药联合会道地药材多维评价专委会常务理事、重庆市中医药行业协会副理事长、重庆市药学教学指导委员会委员等。担任国家科技奖评审专家、国家教学成果奖评审专家、教育部本科专业审核评估专家、国家自然科学基金通讯评议人、国家中医药管理局中医药标准咨询专家等。国家一流课程、重庆市一流课程、重庆市课程思政示范课程负责人。
研究方向
1.活性成分研究：聚焦临床有效中藏药，开展药物活性成分提取、分离及结构解析。
2.药理学研究：针对代谢性肝病、类风湿性关节炎等，评价药效、发现药物作用靶点与机制。
3.药物质量控制：利用HPLC-MS等方法开展药物质量控制研究。
部分项目：
1.国家自然基金面上项目，82274202，2023-2026。
2.国家自然基金面上项目，82074119，2021-2024。
3.国家自然基金面上项目，81774005，2018-2021。
4.重庆市技术创新与应用发展专项重点项目，CSTB2025TIAD-KPX0093，2025-2028。
5.重庆市科卫联合中医药科研重点项目，2026ZYZD005，2026-2028。
6.宜宾市双城市校协议专项科研经费科技项目，YBSCXY2025010018，2026-2028。
7.西藏自治区科技厅科技创新团队子课题，ZFYC202401001TD，2026-2028.
8.中国中医科学院名贵中药资源可持续利用能力建设项目，2060302，2024-2026.
部分通讯作者文章：
1. Zhaoyue Dong, Yulu Xie, Kun Wu, Pingping Wang, Honghong Zhan, Lingjiang Zeng, Mohammad Mahmoud Nagdy, Fancheng Meng*, Zhihua Liao, Dan Li* and Min Chen*. Discovery of Diverse Esterified seco-Polycyclic olyprenylated Acylphloroglucinols from Two Species of Hypericum Linn. and Their Lipid-Lowering Effect. Organic letters, 2026, 28(6): 2062-2068 https://doi.org/10.1021/acs.orglett.5c05350.
2. Zhaoyue Dong, Chengdan Meng, Fanghua Xu, Pingping Wang, Chengyan Long, Ran Ye, Yan Qian, Mohammad Mahmoud Nagdy, Zhihua Liao, Fancheng Meng, Min Chen*. Discovery of Diverse Polycyclic Polyprenylated Acylphloroglucinols from Hyperi-cum kouytchense with Anti-liver Fibrosis Potential. Organic letters, 2026, 28 (37): 11836–11842. https://doi.org/10.1021/acs.orglett.6c03738
3. Lin Jing#, Yixuan Liao#, Honghong Zhan, Qianyu Chen, Xiaodong Wei, Yinda Qiu, Fancheng Meng, Zhihua Liao, Min Chen*. Herpetrione alleviates ANIT-induced cholestatic liver injury by targeting FXR to suppress NF-κB signaling. Journal of Ethnopharmacology, 2026, 356, 120839. https://doi.org/10.1016/j.jep.2025.120839.
4. Feng Ju, Jianyu Xiang, Honghong Zhan, Yinda Qiu, Zhaoyue Dong, Fancheng Meng, Zhihua Liao, and Min Chen*. Sesquiterpenoid Dimers from the Roots of Two Species of the Genus Inula with Cytotoxic Activity on Hepatocellular Carcinoma Cells. Journal of Natural Products, 2026. https://doi.org/10.1021/acs.jnatprod.6c00758
5. Hongxu Zhou, Yi Zhang, Jingyi Yan, Jun Zeng, Mingming Qiao, Xiaohu Chen, Lei Sun*, En Zhang*, Min Chen*. A streamlined analytical strategy combining plant metabolomics and interpretable machine learning for detecting homologous adulteration in Panax notoginseng powder. Journal of Pharmaceutical and Biomedical Analysis, 2026, 281, 117644. https://doi.org/10.1016/j.jpba.2026.117644.
6. Zhuoqing Cheng, Honghong Zhan, Han Yuan, Nan Wang, Yi Lan, Weijian Qu, Xiaozhong Lan, Zhihua Liao, Guowei Wang, Min Chen*. Boeravinone C ameliorates lipid accumulation and inflammation in diabetic kidney disease by activating PPARα signaling. Journal of Ethnopharmacology, 2025, 342, 119398. https://doi.org/10.1016/j.jep.2025.119398.
7. Zhaoyue Dong, Pingping Wang, Qingju Liu, Feng Ju, Miaomiao Sun, Mohammad Mahmoud Nagdy, Fancheng Meng, Guowei Wang, Zhihua Liao, Min Chen*. Salcastaniols A-G, seven undescribed diterpenoids with cholinesterase inhibitory activities from Salvia castanea Diels f. tomentosa Stib. Phytochemistry, 2025, 235, 114472. https://doi.org/10.1016/j.phytochem.2025.114472
8. Zhaoyue Dong, Qingxiu Pu, Yinda Qiu, Ruifeng Zhang, Qianyu Chen, Ammara Khalid, Fancheng Meng, Guowei Wang, Zhihua Liao, and Min Chen*. (±)- (±)-Hypernumqulins A-H: Eight pairs of unexpected [2+2] cycloaddition sesquiterpenoid alkaloid with 6/6/6/4/10 ring system from Hypericum monogynum L. Bioorganic Chemistry, 2024, 150, 107564. https://doi.org/10.1016/j.bioorg.2024.107564.
9. Miaomiao Sun, Honghong Zhan, Xiaoliang Long, Ali M. Alsayed, Zhe Wang, Fancheng Meng, Guowei Wang, JingXin Mao, Zhihua Liao, and Min Chen*. Dehydrocostus lactone alleviates irinotecan-induced intestinal mucositis by blocking TLR4/MD2 complex formation. Phytomedicine, 2024, 128, 155371. https://doi.org/10.1016/j.phymed.2024.155371
10. Lang Linghu, Wei Zong, Yixuan Liao, Qianyu Chen, Fancheng Meng, Guowei Wang, Zhihua Liao, Xiaozhong Lan, Min Chen*. Herpetrione, a new type of PPARα ligand as a therapeutic strategy against nonalcoholic steatohepatitis. Research, 2023, 6: 0276，DOI: 10.34133/research.0276
11. Fancheng Meng#, YingXiong Ma#, HongHong Zhan, Wei Zong, Lang Linghu, Zhe Wang, XiaoZhong Lan, ZhiHua Liao, and Min Chen*. Lignans from the seeds of Herpetospermum pedunculosum and their farnesoid X receptor-activating effect. Phytochemistry. 2022, 193, 113010. https://doi.org/10.1016/j.phytochem. 2021.113010.
12. Xiaodong Wei, Yingxiong Ma, Zhaoyue Dong, Guowei Wang, Xiaozhong Lan, Zhihua Liao, and Min Chen*. Dehydrodiconiferyl alcohol, a lignan from Herpetospermum pedunculosum, alleviates cholestasis by activating pathways associated with the farnesoid X receptor. Phytomedicine. 2021, 80: 153378. https://doi.org/10.1016/j.phymed.2020.153378
13. Honghong Zhan, Qingxiu Pu, Xiaoliang Long, Wei Lu, Guowei Wang, Fancheng Meng, Zhihua Liao, Xiaozhong Lan and Min Chen*. Oxybaphus himalaicus Mitigates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting TLR4/MD2 Complex Formation. Antioxidants. 2022, 11, 2307. https://doi.org/10.3390/antiox11122307
14. Rui Wang, Zhaoyue Dong, Fancheng Meng, Lin Wei, Guowei Wang, Siyu Zhou, Xiaozhong Lan, Zhihua Liao, and Min Chen *. Pterocephin A, a novel triterpenoid saponin from Pterocephalus hookeri induced liver injury by Activation of Necroptosis. Phytomedicine. 2021, 85, 153548. https://doi.org/10.1016/ j.phymed.2021.153548
15. Fancheng Meng, Wei Zong, XiaoDong Wei, YunYi Tao, Guowei Wang, ZhiHua Liao, and Min Chen*. Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism. Phytomedicine. 2021, 87, 153588. https://doi.org/10.1016/j.phymed.2021.153588
