邹懿

发布时间:2013-09-01 11:35:00 作者: 浏览次数: 次

 

 

邹懿,博士,西南大学“含弘英才岗”教授,博士生导师。

       

国家海外高层次引进人才计划青年项目(2018)。重庆市学术技术带头人(2019)。重庆市教育系统优秀共产党员(2019)。重庆市杰出青年基金获得者(2020)。重庆市青年专家工作室领衔专家(2021)。西南大学“十三五”科研工作先进个人(2021)。西南大学十佳青年(2022)。中央高校优秀青年团队负责人2023)。

2002-2009年于西南大学药学院,分别获制药工程学士和微生物与生化药学硕士学位。2013年于上海交通大学微生物代谢国家重点实验室获微生物学博士学位,研究方向为链霉菌来源的复杂结构天然产物生物合成,博士学位论文获上海市优秀博士学位论文奖。2014-2017年,在美国加州大学洛杉矶分校(UCLA)从事博士后研究工作,研究方向为真菌来源的复杂结构天然产物酶学合成和催化机理。20177月,通过西南大学“聚贤工程”人才引进加入药学院任职。近几年,以独立通讯作者或共同通讯作者在包括J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nat. Commun., Chem. Sci., ACS Catal., Org. Lett., Acta. Pharm. Sin. B.等国际著名期刊上发表文章数篇,相关成果多次被权威综述性杂志Nat. Prod. Rep.遴选为研究热点报道


热忱欢迎有志于真菌天然药物合成生物学与生物酶催化机理研究的

青年教师、博士后、研究生和本科生加入课题组


联系方式 


E-mail: zouyi31@swu.edu.cn


教育与工作经历

2017. 06 - 至今   西南大学,药学院,教授,博士生导师

2014. 01 - 2017. 01 加州大学洛杉矶分校,化学与分子生物工程学院,博士后

2009. 09 - 2013. 12  上海交通大学,微生物代谢国家重点实验室,微生物学,博士

2006. 09 - 2009. 06  西南大学,药学院,微生物与生化药学,硕士

2002. 09 - 2006. 06  西南大学,药学院,制药工程,学士


研究方向

1. 真菌天然药物生物合成与酶催化机理

2. 真菌天然药物合成生物学与分子创新


主持的基金项目 

1. 国家自然科学基金委面上项目(2022. 01-2025. 1222177093

2. 国家自然科学基金委面上项目(2019. 01-2022. 12,31870022

3. 科技部重点研发计划合成生物学重点专项课题(2023. 12-2028. 11,2023YFA0914203

4. 科技部重点研发计划合成生物学重点专项子课题(2020. 11-2025. 10,2020YFA0907700

5. 国家海外高层次引进人才计划青年项目(A类资助)

6. 重庆市青年专家工作室领衔专家基金

7. 重庆市生物医药研发重大专项课题(2023. 01-2025. 12,CSTB2022TIAD-STX0015

8. 重庆市杰出青年科学基金项目(2020. 09-2023. 08,cstc2020jcyj-jqX0005

9. 重庆市留学生创新创业计划重点项目(2018. 01-2020. 12,cx2018006

10. 西南大学自然科学领域校级青年领军团队项目(2023.07-2026.07,SWU-XJLJ202306

11. 西南大学2035先导计划发展培育项目(2022. 06-2025. 05,SWU-XDPY22009

12. 中央高校业务费重点项目(2018. 04-2019. 12,XDJK2018B035

13. 西南大学“聚贤工程”人才启动基金(2017. 07-2020. 12,SWU117034

14. 企业横向项目(2023.07-2026.07


课题组研究生主持的科研项目

1. 重庆市博士研究生科研创新项目(2024.07-2026.04,CYB240125

2. 重庆市博士研究生科研创新项目(2022.07-2024.04,CYB22142

3. 重庆市硕士研究生科研创新项目(2024.07-2025.04,CYS240174


学术机构任职

 

1. 中国菌物学会药用真菌专业委员会,副主任委员

2.《药学学报》中英文两刊青年编委

3.Green Synthesis & Catalysis》青年编委

4.Chinese Journal of Natural Medicines》青年编委


授权专利

1. 具有抗线虫活性的thermolides类化合物及其制备方法和应用,专利号:ZL202111276470.7


论文发表

 

1. Xu, R., Zou, Y.* Biosynthesis of (−)-Vinigrol. Angew. Chem. Int. Ed. 2024, e202416795.

2. Wang X., Kong, D-K., Zhang, H-R., Zou, Y.* Discovery of a Polyketide Carboxylate Phytotoxin from a Polyketide Glycoside Hybrid by β-glucosidase Mediated Ester Bond Hydrolysis. Chem. Sci. 2024, 15, 17183-17192.

3. Tang, Y.-J., Zou, Y.* Cyclo-farnesyl Diphosphate-Dependent Prenylation in Fungi. Org. Lett. 2024, 26, 8366-8370.

4. Chen, X-W.#, Liu, Z-Y.#, Dai, S-B.*, Zou, Y.* Discovery, Characterization and Engineering of the Free l-Histidine C4-prenyltransferase. J. Am. Chem. Soc. 2024, 146, 23686-23691. (#co-first author; Hot off the Press, Nat. Prod. Rep., 2024, 41, 1466-1470.)

5. Yuan, G-Y.#, Zhang, J-M.#, Xu, Y-Q., Zou, Y.* Biosynthesis and Assembly Logic of Fungal Hybrid Terpenoid Natural Products. ChemBioChem 2024, e202400387. (#co-first author, Invited Review)

6. Zhang, H-R.#, Huang, Y-T.#, Tang, Y.-J., Kong, D-K.*, Zou, Y.* Genome Mining of Multi-substituted Alkylresorcinols from a Hybrid Highly Reducing- and Type III- Polyketide Pathway. Chin. Chem. Lett. 2024, 35, 108968. (#co-first author)

7. He, Q., Zhang, H-R., Zou, Y.* A Cytochrome P450 Catalyses Oxidative Coupling Formation of Insecticidal Dimeric Indole Piperazine Alkaloids. Angew. Chem. Int. Ed. 2024, e202404000. (Hot off the Press, Nat. Prod. Rep., 2024, 41, 1214-1218.)

8. Zhang, H-R.#, Zhao, H-Y.#, Huang, Y-Q., Zou, Y.* Genome Mining Reveals the Biosynthesis of Sativene and Its Oxidative Conversion to seco-Sativene. Org. Lett. 2024, 26, 338-343. (#co-first author) (Hot off the Press, Nat. Prod. Rep., 2024, 41, 520-524.)

9. Yuan, G-Y., Zhang, J-M., Xu, Q-D., Zhang, H-R., Hu, C-H.*, Zou, Y.* Biosynthesis of Cosmosporasides Reveals the Assembly Line for Fungal Hybrid Terpenoid Saccharides. Angew. Chem. Int. Ed. 2023, 62, e202308887. (Hot off the Press, Nat. Prod. Rep., 2023, 40, 1816-1821.)

10. Rao, L., Yuan G-Y., Chen, X-Y., Ran, J-L., Zou, Y.* Reshaping the Diversity of Oxidized Polyquinane Sesquiterpenoids by Cytochrome P450s. Org. Lett. 2023, 25, 3276-3280.

11. Chen, X-W., Rao, L., Chen, J-L., Zou, Y.* Unexpected Assembly Machinery for 4(3H)-Quinazolinone Scaffold Synthesis. Nat. Commun. 2022, 13: 6522.

12. Rao, L.#, Shi, H-C.#, Zou, Y.* A Fungal Nonribosomal Peptide-Polyketide Hybrid Synthase Synthesizes 2-Pyrrolidinone Alkaloid. Tetrahedron. 2022, 125: 133060. (#co-first author, Special Issue entitled “Frontiers in biosynthesis”, Invited Paper; Hot off the Press, Nat. Prod. Rep., 2022,39, 2209-2214.)

13. Liu, L., Chen, X-W.*, Zou, Y.* Genome Mining of Fungal Globin-like Enzymes for Catalyzing the Synthesis of Linear Terpenes. Chin. J. Nat. Med. 2022, 20, 795-800. (Invited Paper)

14. Wei, Q.#, Wang, Z-P.#, Zhang, X.*, Zou, Y.* Diaryl Ether Formation by a Versatile Thioesterase Domain. J. Am. Chem. Soc. 2022, 144, 9554-9558. (#co-first author, Highlighted by ChemistryViews; Hot off the Press, Nat. Prod. Rep., 2022, 39, 1539-1543.)

15. Zhang, J-M.#, Liu, X.#, Wei, Q., Ma, C-T., Li, D-H., Zou, Y.* Berberine Bridge Enzyme-like Oxidase-Catalysed Double Bond Isomerization Acts as the Pathway Switch in Cytochalasin Synthesis. Nat. Commun. 2022, 13: 225. (#co-first author)

16. Cai, Y., Rao, L., Zou, Y.* Genome Mining Discovery of a C4‑Alkylated Dihydroisocoumarin Pathway in Fungi. Org. Lett. 2021, 23, 2337-2341.

17. Wei, Q., Zeng, H-C., Zou, Y.* Divergent Biosynthesis of Fungal Dioxafenestrane Sesquiterpenes by the Cooperation of Distinctive Baeyer-Villiger Monooxygenases and α-Ketoglutarate-Dependent Dioxygenases. ACS Catal. 2021, 11, 948-957.

18. Zhang, J-M., Wang, H-H., Liu, X., Hu, C-H., Zou, Y.* Heterologous and Engineered Biosynthesis of Nematocidal Polyketide-Nonribosomal Peptide Hybrid Macrolactone from Extreme Thermophilic Fungi. J. Am. Chem. Soc. 2020, 142, 1957-1965.

19. Zeng, H-C., Yin, G-P., Wei, Q., Li, D-H., Wang, Y., Hu, Y-C., Hu, C-H.*, Zou, Y.* Unprecedented [5.5.5.6]Dioxafenestrane Ring Construction in Fungal Insecticidal Sesquiterpene Biosynthesis. Angew. Chem. Int. Ed. 2019, 58, 6569-6573. (Hot off the Press, Nat. Prod. Rep., 2019, 36, 1039-1043.)

20. Feng, C., Wei, Q., Hu, C-H.*, Zou, Y.* Biosynthesis of Diphenyl Ethers in Fungi. Org. Lett. 2019, 21, 3114-3118.

21. Chen, X-W., Wang, L., Zhang, J-M., Jiang, T., Hu, C-H., Li, D-H.*, Zou, Y.* Immunosuppressant Mycophenolic Acid Biosynthesis Employs a New Globin-like Enzyme for Prenyl Side Chain Cleavage. Acta. Pharm. Sin. B. 2019, 9, 1253-1258.