邹懿，博士，西南大学“含弘英才岗”教授，博士生导师。
国家海外高层次引进人才计划青年项目（2018）。重庆市学术技术带头人（2019）。重庆市教育系统优秀共产党员（2019）。重庆市杰出青年基金获得者（2020）。重庆市青年专家工作室领衔专家（2021）。西南大学“十三五”科研工作先进个人（2021）。西南大学十佳青年（2022）。中央高校优秀青年团队负责人（2023）。
2002-2009年于西南大学药学院，分别获制药工程学士和微生物与生化药学硕士学位。2013年于上海交通大学微生物代谢国家重点实验室获微生物学博士学位，研究方向为链霉菌来源的复杂结构天然产物生物合成，博士学位论文获上海市优秀博士学位论文奖。2014年-2017年，在美国加州大学洛杉矶分校（UCLA）从事博士后研究工作，研究方向为真菌来源的复杂结构天然产物酶学合成和催化机理。2017年7月，通过西南大学“聚贤工程”人才引进加入药学院任职。近几年来，以通讯作者或第一作者身份在包括Chem. Rev., Nat. Chem. Biol., Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Sci., ACS Catal., Org. Lett., Acta. Pharm. Sin. B.等国际著名期刊上发表文章数篇，相关成果入选web of science高被引论文，被权威综述性杂志Nat. Prod. Rep.遴选为年度研究热点报道，同时被生物医学论文评价系统F1000 Prime评为杰出论文而被强烈推荐。
热忱欢迎有志于真菌天然药物合成生物学与生物酶催化机理研究的
青年教师、博士后、研究生和本科生加入课题组！
联系方式
E-mail: zouyi31@swu.edu.cn
教育与工作经历
2017. 06 - 至今 西南大学，药学院，教授，博士生导师
2014. 01 - 2017. 01 加州大学洛杉矶分校，化学与分子生物工程学院，博士后
2009. 09 - 2013. 12 上海交通大学，微生物代谢国家重点实验室，微生物学，博士
2006. 09 - 2009. 06 西南大学，药学院，微生物与生化药学，硕士
2002. 09 - 2006. 06 西南大学，药学院，制药工程，学士
研究方向
1. 真菌天然药物生物合成与酶催化机理
2. 真菌天然药物合成生物学与分子创新
主持的基金项目
1. 国家自然科学基金委面上项目（2022. 01-2025. 12，22177093）
2. 国家自然科学基金委面上项目（2019. 01-2022. 12，31870022）
3. 科技部重点研发计划合成生物学重点专项课题（2023. 12-2028. 11，2023YFA0914203）
4. 科技部重点研发计划合成生物学重点专项子课题（2020. 11-2025. 10，2020YFA0907700）
5. 国家海外高层次引进人才计划青年项目（A类资助）
6. 重庆市青年专家工作室领衔专家基金
7. 重庆市生物医药研发重大专项课题（2023. 01-2025. 12，CSTB2022TIAD-STX0015）
8. 重庆市杰出青年科学基金项目（2020. 09-2023. 08，cstc2020jcyj-jqX0005）
9. 重庆市留学生创新创业计划重点项目（2018. 01-2020. 12，cx2018006）
10. 西南大学自然科学领域校级青年领军团队项目（2023.07-2026.07，SWU-XJLJ202306）
11. 西南大学2035先导计划发展培育项目（2022. 06-2025. 05，SWU-XDPY22009）
12. 中央高校业务费重点项目（2018. 04-2019. 12，XDJK2018B035）
13. 西南大学“聚贤工程”人才启动基金（2017. 07-2020. 12，SWU117034）
14. 企业横向项目（2023.07-2026.07）
课题组成员主持的基金项目
1. 国家自然科学基金委面上项目（2023. 01-2026. 12，22277100）
2. 国家自然科学基金委青年项目（2025.01-2027.12，32400059）
3. 国家自然科学基金委青年项目（2025.01-2027.12，32401212）
4. 国家自然科学基金委青年项目（2024.01-2026.12，22307105）
5. 科技部重点研发计划合成生物学重点专项子课题（2023.12-2028.11，2023YFA0914200）
6. 科技部重点研发计划合成生物学重点专项子课题（2023.12-2028.11，2023YFA0914201）
7. 中央高校业务费科研启动项目（2023.01-2025.12，SWU-KQ22034）
8. 国家资助博士后研究人员计划（B档）（2024.01-2025.12，GZB20230603）
9. 中国博士后科学基金第17批特别资助（2024.07-2025.06，2024T170740）
10. 重庆市博士后创新人才支持计划（2023.12-2025.11，7820101068）
11. 重庆市博士后研究项目特别资助(一等)（2023.01-2024.12，2212013361956563）
12. 企业横向项目（2023.05-2024.04）
课题组研究生主持的科研项目
1. 重庆市博士研究生科研创新项目（2024.07-2026.04，CYB240125）
2. 重庆市博士研究生科研创新项目（2022.07-2024.04，CYB22142）
3. 重庆市硕士研究生科研创新项目（2024.07-2025.04，CYS240174）
学术机构任职
1. 中国菌物学会药用真菌专业委员会，副主任委员
2.《药学学报》中英文两刊青年编委
3.《Green Synthesis & Catalysis》青年编委
4.《Chinese Journal of Natural Medicines》青年编委
授权专利
1. 具有抗线虫活性的thermolides类化合物及其制备方法和应用，专利号：ZL202111276470.7
论文发表
代表性论文
Review:
Chem Rev, 2017; ChemBioChem, 2024
Research article:
Nat Chem Biol, 2017
Nat Commun, 2022a; 2022b
J Am Chem Soc, 2024; 2022; 2020; 2015
Angew Chem Int Ed, 2024a; 2024b; 2023; 2019; 2013
Chem Sci, 2024
ACS Catal, 2021
Acta Pharm Sin B, 2019
Org Lett, 2024a; 2024b; 2023; 2021; 2019; 2014
@ 独立建组以来的工作
1. Xu, R., Zou, Y.*. Biosynthesis of (−)-Vinigrol. Angew. Chem. Int. Ed. 2024, DOI: 10.1002/anie.202416795.
2. Wang X., Kong, D-K., Zhang, H-R., Zou, Y.* Discovery of Polyketide Carboxylate Phytotoxin from Polyketide Glycoside Hybrid by β-glucosidase Mediated Ester Bond Hydrolysis. Chem. Sci. 2024, 15, 17183-17192.
3. Tang, Y.-J., Zou, Y.* Cyclo-farnesyl Diphosphate-Dependent Prenylation in Fungi. Org. Lett. 2024, 26, 8366-8370.
4. Chen, X-W.#, Liu, Z-Y.#, Dai, S-B.*, Zou, Y.* Discovery, Characterization and Engineering of the Free l-Histidine C4-prenyltransferase. J. Am. Chem. Soc. 2024, 146, 23686-23691. (#co-first author; Hot off the Press, Nat. Prod. Rep., 2024, 41, 1466-1470.)
5. Yuan, G-Y.#, Zhang, J-M.#, Xu, Y-Q., Zou, Y.* Biosynthesis and Assembly Logic of Fungal Hybrid Terpenoid Natural Products. ChemBioChem 2024, e202400387. (#co-first author, Invited Review)
6. Zhang, H-R.#, Huang, Y-T.#, Tang, Y.-J., Kong, D-K.*, Zou, Y.* Genome Mining of Multi-substituted Alkylresorcinols from a Hybrid Highly Reducing- and Type III- Polyketide Pathway. Chin. Chem. Lett. 2024, 35, 108968. (#co-first author)
7. He, Q., Zhang, H-R., Zou, Y.* A Cytochrome P450 Catalyses Oxidative Coupling Formation of Insecticidal Dimeric Indole Piperazine Alkaloids. Angew. Chem. Int. Ed. 2024, e202404000. (Hot off the Press, Nat. Prod. Rep., 2024, 41, 1214-1218.)
8. Zhang, H-R.#, Zhao, H-Y.#, Huang, Y-Q., Zou, Y.* Genome Mining Reveals the Biosynthesis of Sativene and Its Oxidative Conversion to seco-Sativene. Org. Lett. 2024, 26, 338-343. (#co-first author) (Hot off the Press, Nat. Prod. Rep., 2024, 41, 520-524.)
9. Yuan, G-Y., Zhang, J-M., Xu, Q-D., Zhang, H-R., Hu, C-H.*, Zou, Y.* Biosynthesis of Cosmosporasides Reveals the Assembly Line for Fungal Hybrid Terpenoid Saccharides. Angew. Chem. Int. Ed. 2023, 62, e202308887. (Hot off the Press, Nat. Prod. Rep., 2023, 40, 1816-1821.)
10. Rao, L., Yuan G-Y., Chen, X-Y., Ran, J-L., Zou, Y.* Reshaping the Diversity of Oxidized Polyquinane Sesquiterpenoids by Cytochrome P450s. Org. Lett. 2023, 25, 3276-3280.
11. Chen, X-W., Rao, L., Chen, J-L., Zou, Y.* Unexpected Assembly Machinery for 4(3H)-Quinazolinone Scaffold Synthesis. Nat. Commun. 2022, 13: 6522.
12. Rao, L.#, Shi, H-C.#, Zou, Y.* A Fungal Nonribosomal Peptide-Polyketide Hybrid Synthase Synthesizes 2-Pyrrolidinone Alkaloid. Tetrahedron. 2022, 125: 133060. (#co-first author, Special Issue entitled “Frontiers in biosynthesis”, Invited Paper; Hot off the Press, Nat. Prod. Rep., 2022,39, 2209-2214.)
13. Liu, L., Chen, X-W.*, Zou, Y.* Genome Mining of Fungal Globin-like Enzymes for Catalyzing the Synthesis of Linear Terpenes. Chin. J. Nat. Med. 2022, 20, 795-800. (Invited Paper)
14. Wei, Q.#, Wang, Z-P.#, Zhang, X.*, Zou, Y.* Diaryl Ether Formation by a Versatile Thioesterase Domain. J. Am. Chem. Soc. 2022, 144, 9554-9558. (#co-first author, Highlighted by ChemistryViews; Hot off the Press, Nat. Prod. Rep., 2022, 39, 1539-1543.)
15. Zhang, J-M.#, Liu, X.#, Wei, Q., Ma, C-T., Li, D-H., Zou, Y.* Berberine Bridge Enzyme-like Oxidase-Catalysed Double Bond Isomerization Acts as the Pathway Switch in Cytochalasin Synthesis. Nat. Commun. 2022, 13: 225. (#co-first author)
16. Cai, Y., Rao, L., Zou, Y.* Genome Mining Discovery of a C4‑Alkylated Dihydroisocoumarin Pathway in Fungi. Org. Lett. 2021, 23, 2337-2341.
17. Wei, Q., Zeng, H-C., Zou, Y.* Divergent Biosynthesis of Fungal Dioxafenestrane Sesquiterpenes by the Cooperation of Distinctive Baeyer-Villiger Monooxygenases and α-Ketoglutarate-Dependent Dioxygenases. ACS Catal. 2021, 11, 948-957.
18. Zhang, J-M., Wang, H-H., Liu, X., Hu, C-H., Zou, Y.* Heterologous and Engineered Biosynthesis of Nematocidal Polyketide-Nonribosomal Peptide Hybrid Macrolactone from Extreme Thermophilic Fungi. J. Am. Chem. Soc. 2020, 142, 1957-1965.
19. Zeng, H-C., Yin, G-P., Wei, Q., Li, D-H., Wang, Y., Hu, Y-C., Hu, C-H.*, Zou, Y.* Unprecedented [5.5.5.6]Dioxafenestrane Ring Construction in Fungal Insecticidal Sesquiterpene Biosynthesis. Angew. Chem. Int. Ed. 2019, 58, 6569-6573. (Hot off the Press, Nat. Prod. Rep., 2019, 36, 1039-1043.)
20. Feng, C., Wei, Q., Hu, C-H.*, Zou, Y.* Biosynthesis of Diphenyl Ethers in Fungi. Org. Lett. 2019, 21, 3114-3118.
21. Chen, X-W., Wang, L., Zhang, J-M., Jiang, T., Hu, C-H., Li, D-H.*, Zou, Y.* Immunosuppressant Mycophenolic Acid Biosynthesis Employs a New Globin-like Enzyme for Prenyl Side Chain Cleavage. Acta. Pharm. Sin. B. 2019, 9, 1253-1258.
@ 独立建组之前的工作
1. Zou, Y., Garcia-Borràs, M., Tang, M-C., Hirayama, Y., Li, D., Li, L., Watanabe, K., Houk, K. N.*, Tang, Y.* Enzyme-Catalyzed Cationic Epoxide Rearrangements in Quinolone Alkaloid Biosynthesis. Nat. Chem. Biol. 2017, 13, 325-332. (Recommended as the exceptional paper by F1000 Prime)
2. Tang, M-C.#, Zou, Y.#, Watanabe, K., Walsh, C. T.*, Tang, Y.* Oxidative Cyclization in Natural Product Biosynthesis. Chem. Rev. 2017, 117, 5226-5333. (#co-first author, web of science, most-cited papers)
3. Zou, Y., Zhan, Z., Li, D., Tang, M-C., Cacho, R., Watanabe, K., Tang, Y.* Tandem Prenyltransferases Catalyze Isoprenoid Elongation and Complexity Generation in Biosynthesis of Quinolone Alkaloids. J. Am. Chem. Soc. 2015, 137, 4980-4983. (Hot off the Press, Nat. Prod. Rep. 2015, 32, 1165-1169.)
4. Zou, Y.#, Xu, W.#, Tsunematsu, Y., Tang, M-C., Watanabe, K., Tang, Y.* Methylation-Dependent Acyl Transfer between Polyketide Synthase and Nonribosomal Peptide Synthetase Modules in Fungal Natural Product Biosynthesis. Org. Lett. 2014, 16, 6390-6393. (#co-first author)
5. Zou, Y., Fang, Q., Yin, H., Liang, Z., Kong, D., Bai, L., Deng, Z., Lin, S.* Stereospecific Biosynthesis of β-Methyltryptophan from l-Tryptophan Features a Stereochemical Switch. Angew. Chem. Int. Ed. 2013, 52, 12951-12955.
6. Zou, Y., Yin, H., Kong, D., Deng, Z., Lin, S.* A Trans-acting Ketoreductase in Biosynthesis of a Symmetric Polyketide Dimer SIA7248. ChemBioChem 2013, 14, 679-683.
7. Tang, M-C.#, Zou, Y.#, Yee, D., Tang, Y.* Identification of the Pyranonigrin A Biosynthetic Gene Cluster by Genome Mining in Penicillium thymicola IBT 5891. AIChE Journal. 2018, 64, 4182-4186. (#co-first author)
8. Yan, D-J., Chen, Q-B., Gao, J., Bai, J., Liu, B-Y., Zhang, Y-L., Zhang, L., Zhang, C., Zou, Y., Hu, Y-C.* Complexity and Diversity Generation in the Biosynthesis of Fumiquinazoline-Related Peptidyl Alkaloids. Org. Lett. 2019, 21, 1475-1479.
9. Huang, T., Duan, Y., Zou, Y., Deng, Z., Lin, S.* NRPS Protein MarQ Catalyzes Flexible Adenylation and Specific S-Methylation. ACS Chem. Biol. 2018, 13, 2387-2391.
10. Duan, Y., Liu, Y., Huang, T., Zou, Y., Huang, T., Hu, K., Deng, Z., Lin, S.* Divergent Biosynthesis of Indole Alkaloids FR900452 and Spiro-maremycins. Org. Biomol. Chem. 2018, 16, 5446-5451.
11. Bai, J., Yan, D., Zhang, T., Guo, Y, Liu, Y., Zou, Y., Tang, M-C., Liu, B., Wu, Q., Yu, S.*, Tang, Y.*, Hu, Y-C.* A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A. Angew. Chem. Int. Ed. 2017, 56, 4782-4786.
12. Zhang, Y., Zou, Y., Brock, N. L., Huang, T., Lan, Y., Wang, X., Deng, Z., Tang, Y., Lin, S.* Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily. J. Am. Chem. Soc. 2017, 139, 11887-11894.
13. Liu, N., Hung, Y., Gao, S-S., Hang, L., Zou, Y., Chooi, Y-H.*, Tang, Y.* Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway. Org. Lett. 2017, 19, 3560-3563.
14. Yu, X., Liu, F., Zou, Y., Tang, M-C., Hang, L., Houk, K. N.*, Tang, Y.* Biosynthesis of Strained Piperazine Alkaloids- Uncovering the Concise Pathway of Herquline A. J. Am. Chem. Soc. 2016, 138, 13529-13532.
15. Li, L., Yu, P., Tang, M-C., Zou, Y., Gao S-S., Hung, Y-S., Zhao, M-X., Watanabe, K., Houk, K. N.*, Tang, Y.* Biochemical Characterization of a Eukaryotic Decalin-Forming Diels-Alderase. J. Am. Chem. Soc. 2016, 138, 15837-15840.
16. Han, M.#, Yin, H.#, Zou, Y., Brock, N. L., Huang, T., Deng, Z., Chu, Y.*, Lin, S.* An Acyl Transfer Reaction Catalyzed by an Epimerase MarH. ACS Catal. 2016, 6, 788-792. (#co-first author)
17. Lan, Y., Zou, Y., Huang, T., Wang, X., Brock, N. L., Deng, Z., Lin, S.* Indole Methylation Protects Diketopiperazine Configuration in the Maremycin Biosynthetic Pathway. Sci. China. Chem. 2016, 59, 1224-1228.
18. Kong, D., Zou, Y., Zhang, Z., Xu, F., Brock, N. L., Zhang, L., Deng, Z., Lin, S.* Identification of (2S,3S)-β-Methyltryptophan as the Real Biosynthetic Intermediate of Antitumor Agent Streptonigrin. Sci. Rep. 2016, 6, 20273.
19. Tang, M-C., Lin, H-C., Li, D., Zou, Y., Li, J., Xu, W., Cacho, R. A., Hillenmeyer, M., Garg, N. K., Tang, Y.* Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast. J. Am. Chem. Soc. 2015, 137, 13724-13727.
