俸珊 (Feng Shan)

电话：15310918398

邮件：fengshan@swu.edu.cn

中药学博士，副教授，硕士生导师。美国宾夕法尼亚大学（莫奈尔化学感官研究中心）访问学者；中华中医药学会中药基础理论分会委员；重庆市卒中协会科普分会副主任委员；中国药理学会会员。以通讯作者在Brain behavior and immunity等杂志发表SCI论文20余篇。Phytomedicine, Journal of Pain Research和Annals of Advances in Chemistry杂志审稿人。研究方向：1.中药药性基础理论研究；2.降尿酸大健康产品开发。

科研项目（课题）情况

1. 国家自然科学基金青年项目，基于甜味受体探索甘味补气中药的免疫调节作用机制；主持

2. 重庆市基础科学与前沿技术研究专项，基于活性代谢产物评价五味子潜在肝损伤风险及其机制，主持

3. 教育部博士后面上项目，五味子长期用药潜在肝损伤风险及其机制研究，主持

4. 国家自然科学基金面上项目，剪接因子U2AF2通过介导CD44s/v亚型转化调控黑色素瘤转移中力学信号转导分子机制，参加

5. 西南大学基本科研业务费，五味子乙素对氯氮平肝毒性防护机制研究，主持

6. 西南大学博士基金，联苯双酯不同给药策略对雷公藤多苷片肝毒性防治研究，主持

7. 国家自然科学基金面上项目，基于"EPO是肾精的物质之一"假说和"脑神经血管单元体外模型"的补肾益精健脑机制研究，参加

8. 国家自然科学基金面上项目，基于活性中间产物的中药肝毒性成分早期发现系列关键技术，参加

9. 华润三九医药股份有限公司, 横向, 2023500013000028, 芡实等3个品种配方颗粒特征图谱研究, 主持

10. 华润三九医药股份有限公司, 横向, 2021500013000285, 麸炒川泽泻配方颗粒工艺及标准研究, 主持

11. 华润三九医药股份有限公司, 横向, 2021500013000117, 芡实等3个品种配方颗粒工艺及标准研究, 主持

期刊论文

1. Hu W, Zou L, Yu N, Wu Z, Yang W, Wu T, Liu Y, Pu Y, Jiang Y, Zhang J, Zhu H, Cheng F, Feng S. Catalpol rescues LPS-induced cognitive impairment via inhibition of NF-Κb-regulated neuroinflammation and up-regulation of TrkB-mediated BDNF secretion in mice. J Ethnopharmacol. 2024 Jan 30;319(Pt 3):117345.

2. Zhizhongbin Wu; Yilin Huang; Weiqing Hu; Liyin Ren; Peihua Jiang; Robert F Margolske; Hong Wang; Shan Feng ; Lipopolysaccharide-induced inflammation increases nitric oxide production in taste buds, Brain Behav Immun., 2022, 103: 145-153.

3. Ke Liu; Guoran Wan; Ruhong Jiang; Li Zou; Dong Wan; Huifeng Zhu; Shan Feng; Astragalus injection ameliorates lipopolysaccharide-induced cognitive decline via relieving acute neuroinflammation and BBB damage and upregulating the BDNF-CREB pathway in mice, Pharm Biol, 2022, 60: 825-839

4. Feng S, Achoute L, Margolskee RF, Jiang P, Wang H. Lipopolysaccharide-Induced Inflammatory Cytokine Expression in Taste Organoids. Chem Senses. 2020 Apr 17;45(3):187-194.

5. Feng S, Qiu B, Zou L, Liu K, Xu X, Zhu H. Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver.Drug Des Devel Ther. 2018 Nov 23;12:4033-4046.

6.Feng S, Zou L, Wang H, He R, Liu K, Zhu H. RhoA/ROCK-2 Pathway Inhibition and Tight Junction Protein Upregulation by Catalpol Suppresses Lipopolysaccaride-Induced Disruption of Blood-Brain Barrier Permeability. Molecules. 2018 Sep 17;23(9). pii: E2371.

7.Feng S, He X, Zhong P, Zhao J, Huang C, Hu Z. A Metabolism-Based Synergy for Total Coumarin Extract of Radix Angelicae Dahuricae and Ligustrazine on Migraine Treatment in Rats. Molecules. 2018.

8.Hai Y, Feng S, Wang L, Ma Y, Zhai Y, Wu Z, Zhang S, He, X. Coordination Mechanism and Bio-Evidence: Reactive γ-Ketoenal Intermediated Hepatotoxicity of Psoralen and Isopsoralen Based on Computer Approach and Bioassay.Molecules 2017, 22(9), 1451.

9. Zhang P^#*, Feng S^#, Liu G, Wang H, Zhu H, Ren Q, Bai H, Fu C, Dong C. Mutant B-Raf (V600E) promotes melanoma paracellular transmigration by inducing thrombin-mediated endothelial junction breakdown. Journal of Biological Chemistry.2016, 29;291(5):2087-106.

10. Pu Zhang ^#*, Shan Feng^#, Gentao Liu, et al. Suppresses CD44 alternative splicing-dependent melanoma metastasis by mediating U2AF2 ubiquitination and degradation. Oncogene. 2016, 35(38):5056-69.

11. Zhai Y, Wang L, Yang F, Feng G, Feng S, Cui T, An L, He X.The mechanism and risk factors of clopidogrel-induced liver injury.Drug Chem Toxicol. 2016 Oct;39(4):367-74.

8. He X^#* and Feng S, and. Role of metabolic enzymes P450 (CYP) on activating procarcinogen. Curr Drug Metab, 2015,16 (10):850-63.

12. Zhang P^#*, Feng S, Bai H, et.al. Polychlorinated biphenyl quinone induces endothelial barrier dysregulation by setting the cross talk between VE-cadherin, focal adhesion, and MAPK signaling. AJP-Heart and Circulatory, 2015.

13. Yan J^#, He X^*, Feng S, Zhai Y, Ma Y, Liang S, Jin C.Up-regulation on cytochromes P450 in rat mediated by total alkaloid extract from Corydalis yanhusuo. BMC Complement Altern Med. 2014.

14. Martey ON^#, He X^*, Xing H, Deng F, Feng S, Li C, Shi X. Periplocymarin is a potential natural compound for drug development: highly permeable with absence of P-glycoprotein efflux and cytochrome P450 inhibitions. Biopharm Drug Dispos. 2014, 35: 195-206.

15. Feng S^#, and He X^*. Mechanism-Based Inhibition of CYP450: An Indicator of Drug-Induced Hepatotoxicity. Current Drug Metabolism, 2013, 14(9), 921-945

16.邹利, 刘珂, 祝慧凤, 俸珊. 梓醇对高糖致大鼠脑微血管内皮细胞间紧密连接破坏的保护作用研究.中国中药杂志, 2018,43(20):4118-4125.

17. 邱炳勋, 刘珂, 邹利, 祝慧凤, 俸珊. 五味子诱导的 CYPs 和 Nrf2 活化对对乙酰氨基酚急性肝损伤的影响, 中国中药杂志, 2018.

18. 周航宇，王文麒，曹碧晏，邹 利，邱炳勋，陈玉宝，祝慧凤，俸 珊. 马兰提取液对幼年大鼠胃肠功能的影响. 中国药理学通报, 2018, 34(5):739-740.

19. 俸 珊, 俸 娜,付玉颖, 邹 利,刘 珂,任 巧, 徐晓玉. 对乙酰氨基酚对不同妊娠期小鼠肝肾功能的影响及机制研究.中国药理学通报, 2018, 34( 8) : 1120-1125.

20. 刘珂, 邱炳勋, 邹利, 俸珊, 祝慧凤. 黄芪及其有效成分对内皮细胞及其连接的保护作用及机制.中草药， 2016,47(21):3912-3917.

21. 白慧媛, 俸珊. 五味子乙素对氯氮平致小鼠肝损伤的保护作用. 药学学报, 2017 , 52 (3) :390-396

学术奖励

（1）2018年度重庆市科技进步二等奖, 俸珊(10/10);