个人概况

任巧，1988年生，四川人，博士，副教授。主讲《有机化学》、《药物合成反应》等课程。研究方向为手性药物研发及合成方法学。主持了国家自然科学基金、重庆市社会事业与民生保障项目、中央高校基本业务费、中国博士后科学基金、湖北省重点实验室开放基金、西南大学博士基金及横向等项目。在ACS Catal.、Chem. Commun.、Chem. –Eur. J.等SCI刊物上发表论文17篇。

教育及工作经历

2014/08 — 至今         西南大学药学院， 教师

2009/08 — 2014/05   新加坡国立大学，化学学院，博士

2005/09 — 2009/07   四川大学，化学学院，学士

近几年发表论文

      1.       Ren, Q. *, Li, M.; Yuan, L.; Wang, J. * "Recent advances in N-heterocyclic carbene catalyzed achiral synthesis", Org. Biomol. Chem., 2017, 15, 4731-4749.

      2.       Ren, Q. *; Li, M.; Yuan, L. * “Expeditious assembly of fused dihydropyranones via N-heterocyclic carbene-catalyzed tandem Michael addition/lactonization”, Org. Biomol. Chem., 2017, 15, 1329-1333.

      3.       Ren, Q.; Gao, T.; Li, W.; Wan, L.; Hu, Y.; Peng, Y.; Sun, S.; Hu, L.; Wu, M.; Guo, H.; Wang, J. * “A Highly Enantioselective Michael Reaction between α,β-Unsaturated Ketones and Malonic Acid Half-thioesters”, New J. Chem. 2015, 39, 5100-5103.

      4.       Ren, Q.; Sun, S.; Huang, J.; Li, W.; Wu, M.; Guo, H.; Wang, J. * An Enantioselective Cascade Reaction between α,β-Unsaturated Aldehydes and Malonic Half-thioesters: A Rapid Access to Chiral δ-lactones”, Chem. Commun. 2014, 50, 6137–6140.

      5.       Ren, Q.; Wang, J. * “Recent developments in amine-catalyzed non-asymmetric transformations”, Asian J. Org. Chem. 2013, 2, 542–557.

      6.       Ren, Q.; Huang, J. Y.; Wang, L.; Li, W. J.; Liu, H.; Jiang, X. F.; Wang, J.* “Highly efficient assembly of 3‑hydroxy oxindole scaffold via a catalytic decarboxylative [1,2]-addition strategy”, ACS Catal. 2012, 2, 2622–2625.

      7.       Ren, Q.; Siau, W.-Y.; Du, Z. Y.; Zhang, K.; Wang, J.* “Expeditious assembly of a 2-amino-4H-chromene skeleton by using an enantioselective Mannich intramolecular ring cyclization-tautomerization cascade sequence”, Chem. –Eur. J. 2011, 17, 7781–7785.

      8.       Ren, Q.; Gao, Y. J.; Wang, J.* “Chiral indane skeleton based thiourea catalyzed highly stereoselective cascade Michael-enolation-cyclization reaction”, Org. Biomol. Chem. 2011, 9, 5297–5302.

      9.   Ren, Q.; Gao, Y. J.; Wang, J.* “Enantioselective synthesis of densely functionalized pyrano–chromenes via an unpredictable cascade Michael–oxa-Michael–tautomerization sequence”, Chem. –Eur. J. 2010, 16, 13594–13598.

      10.   Zhang, P. *; Feng, S.; Liu, G.; Wang, H.; Zhu, H.; Ren, Q.; Bai, H.; Fu, C.; Dong, C. “Mutant B-Raf (V600E) Promotes Melanoma Paracellular Transmigration by Inducing Thrombin-Mediated Endothelial Junction Breakdown”, J. Biol. Chem. 2016, 291, 2087-2106.

      11.   Zhang, P. * ，Feng, S. ，Liu, G.，Wang, H.，Fu, A.，Zhu, H.，Ren, Q.，Wang, B.，Xu, X.，Bai, H.，Dong, C.，Suppresses CD44 alternativesplicing-dependent melanoma metastasis by mediating U2AF2 ubiquitination anddegradation. Oncogene，2016, 35, 5056-5069.

      12.   Jiang, X. F.; Wang, J.; Ren, Q.; Liu, H. Faming Zhuanli Shenqing 2012, CN 102659662 A 20120912;

      13.   Siau, W.-Y.; Li, W. J.; Xue, F.; Ren, Q.; Wu, M. H.; Sun, S. F.; Guo, H. B.; Jiang, X. F.; Wang, J.* “Catalytic and enantioselective α-functionalization of oxindoles through oxidative reactions with naphthoquinones”, Chem. –Eur. J. 2012, 18, 9491–9495.

      14.   Du, Z. Y.; Zhou, C. G.; Gao, Y. J.; Ren, Q.; Zhang, K.; Cheng, H. S.*; Wang, W.*; Wang, J.* “Expeditious diastereoselective construction of a thiochroman skeleton via a cinchona alkaloid-derived catalyst”, Org. Biomol. Chem., 2012, 10, 36–39.

      15.   Gao, Y. J.; Ren, Q.; Siau, W.-Y.; Wang, J.* “Asymmetric organocatalytic cascade Michael/hemiketalization/retro-Henry reaction of α,β-unsaturated keto esters with α-nitro ketones”, Chem. Commun. 2011, 47, 5819–5821.

      16.   Gao, Y. J.; Ren, Q.; Ang S.-M.; Wang, J.* “Enantioselective organocatalytic Michael-hemiketalization catalyzed by a trans-bifunctional indane thiourea catalyst”, Org. Biomol. Chem. 2011, 9, 3691–3697.

      17.   Gao, Y. J.; Ren, Q.; Wu, H.; Li, M. G.; Wang, J.* “Enantioselective heterocyclic synthesis of spiro chromanone-thiochroman complexes catalyzed by a bifunctional indane catalyst”, Chem. Commun. 2010, 46, 9232–9234 .

      18.   Gao, Y. J.; Ren, Q.; Wang, L.; Wang, J.* “Enantioselective synthesis of coumarins catalyzed by a bifunctional amine-thiourea catalyst”, Chem. –Eur. J. 2010, 16, 13068–13071.

联系方式

邮箱：qren2014@swu.edu.cn

通信地址：重庆市北碚区西南大学药学院，400715