个人信息

龙梦飞，男，汉族，中共党员。本科毕业于西南大学制药工程系，博士毕业于江南大学发酵工程系，主要从事基因线路设计、酶定向进化及生物大分子互作机制研究等研究。参与及主持国家、省部级等项目5项，以一作/通讯（含共同）在Sci Adv, ACS Synth Biol, Bioresour Technol, Food Hydrocolloid, Crit Rev Food Sci Nutr, J Agric Food Chem, Food Biosci, Appl Environ Microbiol, Appl Microbiol Biotechnol, Heliyon,《中国科学：生命科学》,《生物工程学报》等领域权威期刊上发表论文10余篇，其中IF>10分6篇；申请国家发明专利12件，授权7件，参编论著1部；参与制修订行业/团体标准6件；获中国食品科学技术学会技术进步二等奖等奖项5项。

研究方向与兴趣

利用合成生物学、计算生物学等手段开发特色酶工程及细胞改造策略，实现药物及其中间体、高值化学品等高效生物制造。

教育及工作经历

2011.09-2015.09，西南大学药学院，制药工程学士，导师：胡昌华教授 

2015.09-2021.06，江南大学生物工程学院，发酵工程博士，导师：饶志明教授 

2021.07-2023.05，江南大学生物工程学院，助理研究员，导师：夏小乐教授 

2023.06-至今，西南大学药学院，讲师

代表论文

1. Mengfei Long #, Meijuan Xu #, Zhenfeng Ma, Xuewei Pan, Jiajia You, Mengkai Hu, Yu Shao, Taowei Yang, Xian Zhang, Zhiming Rao*. Significantly enhancing production of trans-4-hydroxy-L-proline by integrated system engineering in Escherichia coli. Science Advances, 2020, 6(21):eaba2383.

2. Mengfei Long, Meijuan Xu*, Zhina Qiao, Zhenfeng Ma, Tolbert Osire, Taowei Yang, Xian Zhang, Minglong Shao, Zhiming Rao*. Directed evolution of ornithine cyclodeaminase using an EvolvR-based growth-coupling strategy for efficient biosynthesis of L-proline. ACS Synthetic Biology, 2020, 9(7):1855-1863.

3. Mengfei Long#, Yongchao Cai#, Nan Zheng, Zhi Lu, Wentao Cao, Yaxian Li, Xiaomei Pei, Osire Tolbert, Xiaole Xia*. Clean Monascus pigments production from Chinese rice wine wastes through submerged fermentation. Food Bioscience, 2023,52:102451.

4. Guojuan Yi#, Hanlu Zou#, Tao Long, Tolbert Osire, Lin Wang, Xiaoyun Wei, Mengfei Long*, Zhiming Rao, Guojian Liao*. Novel cytochrome P450s for various hydroxylation of steroids from filamentous fungi. Bioresource Technology, 2023, 130244.

5. Mengfei Long, Xiaomei Pei, Zhi Lu, Duo Xu, Nan Zheng, Yaxian Li, Hanxiao Ge, Wentao Cao, Tolbert Osire, Xiaole Xia*. Effective degradation of anthraquinones in Folium Sennae with Monascus fermentation for toxicity reduce and efficacy enhancement. Heliyon, 2023, 9(8). 

6. Peifeng Duan#, Mengfei Long#, Xian Zhang, Zuyi Liu, Jiajia You, Xuewei Pan, Weilai Fu, Meijuan Xu, Taowei Yang, Minglong Shao, Zhiming Rao*. Efficient 2-O-α-D-glucopyranosyl-sn-glycerol production by single whole-cell biotransformation through combined engineering and expression regulation with novel sucrose phosphorylase from Leuconostoc mesenteroides ATCC 8293. Bioresource Technology, 2023, 129399.

7. Zehua Zhang#, Mengfei Long#, Nan Zheng, Yu Deng, Qiong Wang, Tolbert Osire, Xiaole Xia*. Microstructural, physicochemical properties, and interaction mechanism of hydrogel nanoparticles modified by high catalytic activity transglutaminase crosslinking. Food Hydrocolloids, 2024, 147, part A:109384.

8. Nan Zheng#, Mengfei Long#, Zehua Zhang, Qijia Zan, Tolbert Osire, Huimin Zhou, Shuang Du, Xiaole Xia*. Functional, structural properties and interaction mechanism of soy protein isolate nanoparticles modified by high-performance protein-glutaminase. Food Hydrocolloids, 2022,139:108594. 

9. Nan Zheng#, Mengfei Long#, Zehua Zhang, Shuang Du, Xinlei Huang, Tolbert Osire, Xiaole Xia*. Behavior of enzymes under high pressure in food processing: mechanisms, applications, and developments. Critical Reviews in Food Science and Nutrition, 2023,1-15.

10. Nan Zheng#, Mengfei Long#, Zehua Zhang, Qijia Zan, Tolbert Osire, Huimin Zhou, Xiaole Xia*. Protein-glutaminase engineering based on isothermal compressibility perturbation for enhanced modification of soy protein isolate. Journal of Agricultural and Food Chemistry, 2022, 70(43), 13969–13978. (Cover story)

11. Zehua Zhang#, Mengfei Long#, Nan Zheng, Xiang Lv, Cailin Zhu, Tolbert Osire, Xiaole Xia*. Inside-out computational redesign of cavities for improving thermostability and catalytic activity of Rhizomucor miehei Lipase. Applied and Environmental Microbiology, 2023, e02172-22.

12. Zehua Zhang#, Mengfei Long#, Nan Zheng, Yu Deng, Qiong Wang, Tolbert Osire, Xiaole Xia. Redesign of γ-glutamyl transpeptidase from Bacillus subtilis for high-level production of L-theanine by cavity topology engineering. Applied Microbiology and Biotechnology, 2023, 107, 3551-3564.

13. Qijia Zan#, Mengfei Long#, Nan Zheng, Zehua Zhang, Huimin Zhou, Xinjie Xu, Tolbert Osire, Xiaole Xia*.  Improving ethanol tolerance of ethyl carbamate hydrolase by diphasic high pressure molecular dynamic simulations. AMB Express. 2023. 13, 32.

14. Xue Dong#, Mengfei Long#, Hongxia Liu, Ling Gao, Xinjie Xu, Xiaole Xia*. Synthesis and characterization of eco-friendly poly(ε-caprolactone) plasticizer facilitating phthalate-free PVC with novel star/net-shaped structures. Journal of Applied Polymer Science, 2023, e53905. (Cover story)

15. Xue Dong#, Mengfei Long#, Yongchao Cai, Zhemin Zhou*, Xiaole Xia*. Novel biologically derived tartaric acid plasticizer: Synthesis and application. Journal of Applied Polymer Science, 2023, e54707.

16. 龙梦飞，徐美娟，张显，杨套伟，邵明龙，许正宏，饶志明*. 合成生物学与代谢工程在谷氨酸棒杆菌产氨基酸中的应用. 中国科学•生命科学, 2019, 49: 1-12

17. 龙梦飞#，郑楠#，张泽华，高玲，王颖妤，夏小乐*. 蛋白质交联用酶的作用机制及研究进展. 生物工程学报, 2022, 38(7): 2499-2512.

(#equal contribution；*corresponding author)

联系方式

邮箱：mengfeilong@swu.edu.cn

地址：重庆市北碚区天生路2号西南大学药学院中医药学院400715