课题组人员：
l 教师：陈敏、王国伟、蒋运斌、肖国君、郭欣
l 博士后：孟凡成
l 在读博士：黄元射、高正山、令狐浪、Mohammad Nagdy
l 在读研究生：董召月、黄丹、韦琳、孙燕、曾庆鸿、宗伟、王喆、詹洪洪、孙苗苗、王茹惠、刘珍秀、刘蝶
研究方向：
l 中药/民族药药效物质基础及创新药研发。课题组专业涉及药物分析、中药化学、药理学等学科领域，主要以中药及民族药为研究对象，从事药效物质基础、药物质量控制、中药体内药代过程、中药治疗作用的分子机理研究以及创新中药研究。
Research interests.
The research interests of our group involve in the elucidation of pharmacodynamic substance basis and the R&D innovative Traditional Chinese Medicine or ethnic medicine. We mainly focus on the isolation and structural elucidation of active constituents from medicinal plants such as Herpetospermum pedunculosum, Sedum sarmentosum, Pterocephalus hookeri, Vladimiria souliei, and Lamiophlomis rotate, et. al., and then the investigation on their therapeutic effect and molecular mechanism, pharmacokinetic process in vivo, drug quality control methods, as well as the development of innovative traditional Chinese medicine.
主要纵向科研项目：
1. 陈敏. 国家自然基金面上项目（82074119），2021-2024.
2. 陈敏. 国家自然基金面上项目（81774005），2018-2021.
3. 陈敏. 国家自然基金青年基金（81102894），2012 - 2014.
4. 陈敏. 国家863项目子课题（2011AA100607），2011 - 2015.
5. 陈敏. 国家科技支撑计划子课题（2011BAI13B06），2011 - 2014.
6. 陈敏. 国家863项目子课题（2010AA101603），2010- 2012.
7. 陈敏. 重庆市科卫联合中医药技术创新与应用发展重点项目 （2020ZY013997），2021-2023.
8. 陈敏. 重庆市社会事业与民生保障科技创新专项（cstc2017shmsA130079），2017-2020.
9. 王国伟. 国家自然科学基金面上项目（82073724），2021-2024.
10. 王国伟. 国家自然科学基金联合基金重点项目子课题（U20A20401）, 2021-2024.
11. 王国伟. 国家自然科学基金青年项目（81602987），2017-2019.
12. 王国伟. 重庆市自然科学基金面上项目（cstc2019jcyj-msxmX0402），2019-2022.
13. 王国伟. 重庆市卫健委与市科技局联合中医药技术创新与应用发展项目（2020ZY3868），2020-2023.
14. 蒋运斌. 重庆市自然科学基金面上项目（cstc2020jcyj-msxmX0146），2020-2023.
代表性论文：
1. Xiaodong Wei, Yingxiong Ma, Zhaoyue Dong, Guowei Wang, Xiaozhong Lan, Zhihua Liao, and Min Chen*. Dehydrodiconiferyl alcohol, a lignan from Herpetospermum pedunculosum, alleviates cholestasis by activating pathways associated with the farnesoid X receptor. Phytomedicine. 2021. 80: 153378.
2. Rui Wang, Zhaoyue Dong, Fancheng Meng, Lin Wei, Guowei Wang, Siyu Zhou, Xiaozhong Lan, Zhihua Liao, and Min Chen *. Pterocephin A, a novel triterpenoid saponin from Pterocephalus hookeri induced liver injury by Activation of Necroptosis. Phytomedicine. 2021. 85, 153548.
3. Xiaodong Wei, Xudong Fan, Zhiying Feng, Yingxiong Ma, Xiaozhong Lan, and Min Chen*. Ethyl acetate extract of Herpetospermum pedunculosum alleviates α-naphthylisothiocyanate-induced cholestasis by activating the farnesoid X receptor and suppressing oxidative stress and inflammation in rats. Phytomedicine. 2020, 76: 153257.
4. Yingxiong Ma, Hong Wang, Rui Wang, Fancheng Meng, Zhaoyue Dong, Guowei Wang, Xiaozhong Lan, Hong Quan* Zhihua Liao and Min Chen*. Cytotoxic lignans from the stems of Herpetospermum pedunculosum. Phytochemistry. 2019，164:102-110.
5. Guowei Wang*,#, Xiaolong Zhang#, Qinghua Wu, Yongbiao Jin, Chuntao Ning, Rui Wang, Jingxin Mao, Min Chen*. The hepatoprotective effects of Sedum sarmentosum extract and its isolated major constituent through Nrf2 activation and NF-κB inhibition. Phytomedicine. 2019, 53: 263-273.
6. Liqing Deng, Wei Zong, Xueying Tao, Shuang Liu, Zhiying Feng, Yuping Lin, Zhihua Liao, and Min Chen*. Evaluation of the Therapeutic Effect against Benign Prostatic Hyperplasia and the Active Constituents from Epilobium angustifolium L. Journal of Ethnopharmacology. 2019, 232: 1-10.
7. Yunbin Jiang*,#, Mei Zhong#, Fei Long, Rongping Yang, Yanfei Zhang *, Tonghua Liu*. Network pharmacology-based prediction of active ingredients and mechanisms of Lamiophlomis rotata (Benth.) Kudo against rheumatoid arthritis. Frontiers in Pharmacology. 2019, 10, 1435.
8. Rui Wang, Zhaoyue Dong, Xiaolong Zhang, Jingxin Mao, Fancheng Meng, Xiaozhong Lan, Zhihua Liao, Min Chen*. Evaluation of the Liver Toxicity of Pterocephalus hookeri Extract via Triggering Necrosis. Toxins 2019, 11, 142.
9. Jingxin Mao, Man Yia, Rui Wang, Yuanshe Huanga and Min Chen*. Protective Effects of Costunolide against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice. Frontiers in Pharmacology. 2018, 9, 1469.
10. Yijie Hu, Liqing Deng, Jinwu Chen, Siyu Zhou, Shuang Liu, Yufan Fu, Chunxian Yang, Zhihua Liao, Min Chen*. An analytical pipeline to compare and characterise the anthocyanin antioxidant activities of purple sweet potato cultivars. Food chemistry. 2016, 194, 46-54.
