Hua Zuo, PhD, Full Professor in College of Pharmaceutical Sciences, Southwest University, Southwest University, No. 2 Tiansheng Road, Beibei, Chongqing, 400715, China
Email: zuohua@swu.edu.cn
Prof. Hua Zuo earned her PhD degree from Changwon National University, South Korea in Feb 2008, and joinedCollege of Pharmaceutical Sciences,Southwest University since then. She visited Purdue University, USA from 2014 to 2015. She has a research expertise in nucleic acid nanotechnology, interactions of biological macromolecules, and nucleic acid drugs and their carriers, and published papers inJ. Am. Chem. Soc.,Angew Chem Int Ed,Adv Drug Deliv Rev,Small, Nanoscale, Sci China Chem, etc.Her research group cooperates with Prof Chengde Mao (Purdue University), who is apioneer in the field of nucleic acid nanotechnology.
Research Interests
Nucleic Acid Nanotechnology
(1)Fabricate nano/microstructured systems to mimic the nuclear environment of the cell and develop experimental and theoretical methods for structural analysis.
(2)Develop DNA computing methods
Interactions of Biological Macromolecules
(1)Systemetically study DNA/RNA-protein hybrid self-assembly methods and construct DNA/protein hybrids
(2)Use highly ordered DNA/RNA-protein structures in hematological diseases
Nucleic Acid Drugs and Their Carriers
(1)Develop therapeutic oligonucleotides like siRNA, aptamer, miRNA, and antisense oligonucleotides
(2)DNA/RNAassisted immunetherapies
(3)mRNA stability investigation
(4)DNA/RNA as nanocarriers for drug delivery
Major Techniques in Our Group Include:
DNA/RNA manipulation (gel electrophoresis, labeling, hybridization, PCR), atomic force microscopy (AFM), electron microscopy (EM), flow cytometry, fluorescence spectroscopy, cell culture, protein expression and purification, Nuclear Magnetic Resonance (NMR), Mass Spectrometry (MS), High Performance Liquid Chromatography (HPLC) and chemical synthesis.
Selected Publications
(1)Hu, X.#;Tang, L.#; Zheng, M.#; Liu, J.; Zhang, Z.; Li, Z.; Yang, Q.; Xiang, S.; Fang, L.; Ren, Q.; Liu, X.; Huang, C. Z.*; Mao, C.*;Zuo, H.*Structure-guided designing pre-organization in bivalent aptamers.J. Am. Chem. Soc.2022, 144, 10, 4507.
(2)Fu,W.; Tang, L.; Wei, G.; Fang, L.; Zeng, J.; Zhan, R.; Liu, X.;Zuo, H.*; Huang, C. Z. *; Mao C.*Angew. Chem. Int. Edit.2019,131, 16557.
(3)Zuo, H.*,Mao, C.*. A minimalist's approach for DNA nanoconstructions.Adv. Drug Deliv.
Rev.2019, 147, 22.
(3)Zeng, J.; Fu, W.; Qi, Z.; Zhu, Q.; He, H.; Huang, C.;Zuo, H.;*Mao, C.*. Self-assembly of
microparticles by supramolecular homopolymerization of one component DNA molecule.Small2019,1805552 (Cover paper).
(4) Tang L.; Tan, J.; Xiang, Y.; Li, Z.; Mao, C.*;Zuo, H.*DNA-NH2acylation reaction:
Molecular weight or conformation dominates?Chinese Science Bulletin,2019,64 (10), 1076 (In Chinese).
(5) Tang L.; C. Z. Huang,Zuo, H.*; Mao, C.*DNA nanotechnology in molecular design of thrombin aptamers.Chinese Science Bulletin,2019,64 (10),1018 (In Chinese).
(6)Zuo, H.; Mao, C*.Drugging the undruggable molecules by a DNA nanorobot.Sci. China
Chem.2018,61(7), 763.
(7) Zuo, H.*; Wu, S.; Li, M.; Li, Y.; Jiang, W.; Mao, C*.A case study of the likes and dislikes of
DNA and RNA in self-assembly.Angew. Chem. Int. Edit.2015,54, 15118 (Inside Cover Paper and Hot Paper).
(8)Li, M.;Zuo, H.*; Yu, J. W.; Zhao, X. F.; Mao, C*. One DNA strand homo- polymerizes into
defined nanostructures.Nanoscale2017,9 (30),10601.
Books Chapters
Chapter 4.3,Nucleic Acid Nanotechnology(Editor: Chunhai Fan, Dongsheng Liu, Shu Wang),
China Science Tech Publishing House, 2021.
Authorized Chinese Patents
(1)Patent No. 201710948200.3;
(2)Patent No. ZL 201710958840.2
(3) Patent No. ZL 200910104093.1.
