Positions:

Education:

Research Areas:

Pharmacology of Traditional Chinese Medicine（TCM）

Stroke & degenerative disease; Neuropsychopharmacology

TCM effects & Mechanisms on Abnormal Glucose and Lipid Metabolism

Slected Publications:

1. WangJinghui#, Zhang Yuhua, Zhang Meifeng, Sun Si,Yang Zhong,Lei Han, Yitong Xu, Dong Wan, Junhui Zhang*, Huifeng Zhu*.Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms. Drug Design, Development and Therapy. 2022;16:279-296

2. Jinghui Wang, Meifeng Zhang, Si Sun, Guoran Wan, Dong Wan, Shan Feng, Huifeng Zhu* Network Pharmacology-Based Prediction of Catalpol and Mechanisms Against stroke. Evidence-Based Complementary and Alternative Medicine. 2021,2021:1-14.

3. Hui-Feng Zhu^#, Dong Wan,Xiao-Yu Xu*. Catalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the Rat after Permanent Middle Cerebral Artery Occlusion. Int. J. Biol.Sci. 2010, 6: 443-453

4. Huifeng Zhu^#, Yuan Wang, Zhiqiang Liu, et al.Antidiabetic and antioxidant effects of catalpol extracted from Rehmannia glutinosa (Di Huang) on rat diabetes induced by streptozotocin and high-fat, high-sugar feed. Chinese Medicine.2016,11:25 doi: 10.1186/s13020-016-0096-7. eCollection.

5. Wan Dong^#; Yang Xian; Zhu Huifeng*; et al. Catalpol Stimulates VEGF Production via the JAK2/STAT3 Pathway to Improve Angiogenesis in a Rat Stroke Model. Journal of Ethnopharmacology. 2016 11.(191):169-179.

6. Wei Tang, Huifeng Zhu*, Yanmei Feng, Rui Guo, Dong Wan*. The Impact of Gut Microbiota Disorders on the Blood-Brain Barrier. Infection and Drug Resistance, 2020:13 3351-3363

7. Zhu Hui Feng^# , Shao Yali^#, Qin Lei^#, et al. Catalpol enhances neurogenesis and inhibits apoptosis of new neurons via BDNF, but not the BDNF/TrkB pathway. Drug Design, Development and Therapy.2019, 13:4145-4157

8. Huifeng Zhu^*, Jinghuan Wang¹, Yali Shao, Dong Wan^2*. Catalpol may improve axonal growth via regulating miR-124 regulated PI3K/AKT/mTOR pathway in neurons after ischemia. Ann transl med, 2019,7(14):306, 1-12.

9. Zhu Huifeng^#; Wang Yuan^#, et al. Catalpol improves axonal outgrowth and reinnervation of injured sciatic nerve by activating Akt/mTOR pathway and regulating BDNF and PTEN expression[J]. American Journal of Translational Research. 2019;11(3):1311-1326

10. Jinghuan Wang^#, Dong Wan^#, Guoran Wan, Huifeng Zhu^*.Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and vitro stroke model. Ann Transl Med 2019;7(23):756, 1-14

11. Xiyue Ye#, Yan Qiu, Yuqing Gao, Dong Wan* and Zhu Hui Feng*. A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues and the Intermediate Role of Signaling Pathways. Neural Plasticity, 2019, 2019:1719829.

12. Lijun Xue^#, Chen Yang Yizhi, Yan Zhiyun, Lu Wei, Dong Wan, Zhu Huifeng*. Staphyloxanthin: a potential target for antivirulence therapy. Infect Drug Resist, 2019:12 2151–2160

13. Yuan Wang^#, Yali Shao, Yuqing Gao, Guoran Wan, Dong Wan, Huifeng Zhu*, Yan Qiu, Xiyue Ye. Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway. Drug Design, Development and Therapy, 2019,13:243–253

14. Shan Feng^#, Binxun Qiu^#, li Zou, Ke liu, Xiaoyu Xu*, Huifeng Zhu *. Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver. Drug Design, Development and Therapy, 2018,12:4033–4046

15. Shan Feng^#, Li Zou^#, Hongjin Wang^#, Ran He, Ke Liu, Huifeng Zhu*. RhoA/ROCK-2 pathway inhibition and tight junction proteins upregulation by catalpol suppresses LPS-induced disruption of BBB permeability. Molecules, 2018,23(9):1-17

16. Wan D^#, Xue L^#, Zhu H*, Luo Y. Catalpol Induces Neuroprotection and Prevents Memory Dysfunction through the Cholinergic System and BDNF. Evidence-Based Complementary and Alternative Medicine. 2013;2013:134852.