Changhua Hu
Ph.D and Professor
College of Pharmaceutical Sciences, Southwest University
Contact information：chhhu@swu.edu.cn; 804152387@qq.com
Research Interest & Scientific Achievements
Mainly engaged in the teaching, scientific research and management of biopharmaceuticals, has undertaken a number of national and Chongqing scientific research projects, published more than 80 papers in core journals at home and abroad, participated in the development of new industrialized drugs and obtained 2 clinical approvals for new drugs, and authorized national inventions. He has 4 patents and won the first prize of technical invention of the Ministry of Education. He led the pharmacy major and won the national first-class professional construction site, and hosted the "Biotechnology Pharmacy" course, which won the first batch of national first-class curriculum construction courses. Editor-in-chief of "Biotechnology Pharmacology", "Introduction to Pharmacy" and "Comprehensive Experiment Course of Drug Preparation" and other pharmacy planning textbooks, won 2 Chongqing Teaching Achievement Awards. National Science and Technology Award review experts, review experts from the National Natural Science Foundation of China, and consulting and review experts for scientific and technological projects in many provinces and cities.
Honors and Social Part-time：
Special Government Allowance Expert of the State Council. Deputy Secretary-General of the Pharmacy Teaching Steering Committee of the Ministry of Education, Secretary-General of the Biopharmaceutical Sub-Committee, Member of the Pharmacy Education Special Committee of the Chinese Pharmaceutical Association, Member of the National Pharmacy Professional Certification Working Committee, Executive Director of the Chongqing Pharmaceutical Association, Director of the Pharmacy Education Special Committee, Chongqing Executive director of the Society for Microbiology, director of Chongqing Pharmaceutical Process and Quality Control Engineering Technology Center.
Member of the Fifth Committee of the CPPCC Chongqing Municipal Committee, Vice Chairman of the Beibei District of the CPPCC, member of the Central Medical and Health Special Committee of the Zhigong Party, Member of the Standing Committee of the Chongqing Municipal Committee, and Chairman of the Beibei District Committee.
Selected Publications
1. Li DJ, Yue Q, Liu L, Che KK, Liu X M, Hu CH., Brexpiprazole caused glycolipid metabolic disorder by inhibiting GLP1/GLP1R signaling in rats. Acta Pharmacol Sin 2021, 42 (8), 1267-1279.
2. Yin GP， Gong M， Xue GM，Gong T，Cao X，Wang W，Hu CH. Penispidins A-C, Aromatic Sesquiterpenoids from Penicillium virgatum and Their Inhibitory Effects on Hepatic Lipid Accumulation. J Nat Prod .2021, 84 (10), 2623-2629.
3. Yin GP, Gong M, Li YJ, Zhang X, Zhu JJ, Hu CH. 14-Membered resorcylic acid lactone derivatives with their anti-inflammatory from the fungus Aspergillus sp. ZJ-65. Fitoterapia. 2021, 151, 104884.
4. Zhang JM, Wang HH, Liu X, Hu CH, Zou Y. Heterologous and Engineered Biosynthesis of Nematocidal Polyketide-Nonribosomal Peptide Hybrid Macrolactone from Extreme Thermophilic Fungi. J Am Chem Soc 2020, 142 (4), 1957-1965.
5. Tian J, Ye L, Yang Y, Zhang Y, Hu CH. Liao G. Transposon-based screen identifies a XRE family regulator crucial for candicidin biosynthesis in Streptomyces albus J1074. Sci China Life Sci 2020, 63 (9), 1421-1424.
6. Liu XM, Wang J, Xu X, Liao GJ, Chen Y, Hu CH. Patterns of IgG and IgM antibody response in COVID-19 patients. Emerg Microbes Infect .2020, 9 (1), 1269-1274.
7. Liu X.M, Feng X, Deng C, Liu L, Zeng Y, Hu CH. Brown adipose tissue activity is modulated in olanzapine-treated young rats by simvastatin. BMC Pharmacol Toxicol 2020, 21 (1), 48.
8. Yin GP, Dan YB, Tong ZB, Wei XC, Hu CH. Wenyujindiol a, a new sesquiterpene from the rhizomes of curcuma wenyujin. Tetrahedron Letters, 2020，61( 44).
9. Zeng HC, Yin GP, Wei Q, Li D, Wang Y, Hu Y, Hu, CH, Zou Y. Unprecedented [5.5.5.6]Dioxafenestrane Ring Construction in Fungal Insecticidal Sesquiterpene Biosynthesis. Angew Chem Int Ed Engl 2019, 58 (20), 6569-6573.
10. Liu XM, Zhao XM, Deng C, Zeng YP, Hu CH. Simvastatin improves olanzapine-induced dyslipidemia in rats through inhibiting hepatic mTOR signaling pathway. Acta Pharmacol Sin 2019, 40 (8), 1049-1057.
11. Feng C, Wei Q, Hu CH, Zou Y. Biosynthesis of diphenyl ethers in fungi. Org Lett 2019, 21 (9), 3114-3118.
12. Chen XW, Wang L, Zhang J, Jiang T, Hu CH, Li DH, Zou Y. Immunosuppressant mycophenolic acid biosynthesis employs a new globin-like enzyme for prenyl side chain cleavage. Acta Pharm Sin B .2019, 9 (6), 1253-1258.
13. Li YJ, Zhang HT, Chen XY, Gao PF, Hu CH. A multifunctional aiegen with high cell-penetrating ability for intracellular fluorescence assays, imaging and drug delivery. Materials Chemistry Frontiers.2019. 3, 1151-1158.
14. Huang X, Ma T, Tian J, Shen L, Zuo H, Hu CH, Liao GJ. WblA, a pleiotropic regulatory gene modulating morphogenesis and daptomycin production inStreptomyces roseosporus. J Appl Microbiol.2017, 123 (3), 669-677.
15. Li Y, Zhao X, Feng X, Liu X, Deng C, Hu CH. Berberine Alleviates Olanzapine-Induced Adipogenesis via the AMPKalpha-SREBP Pathway in 3T3-L1 Cells. Int J Mol Sci 2016, 17 (11).
16. Liu X, Lian J, Hu CH, Deng C. Betahistine co-treatment ameliorates dyslipidemia induced by chronic olanzapine treatment in rats through modulation of hepatic AMPKalpha-SREBP-1 and PPARalpha-dependent pathways. Pharmacol Res. 2015, 100, 36-46.
17. Liu X, Deng C, Cao S, Gong J, Wang BC, Hu CH. Acute effects of oral olanzapine treatment on the expression of fatty acid and cholesterol metabolism-related gene in rats. Life Sci 2015, 128, 72-8.
18. Li Y, Fu J, Yuan X, Hu CH. Simvastatin inhibits the proliferation of A549 lung cancer cells through oxidative stress and up-regulation of SOD2. Pharmazie 2014, 69 (8), 610-4.
19. Liu L, Long L K, An Y, Yang J, Xu X, Hu CH, Liu G. The thioredoxin reductase-encoding gene ActrxR1 is involved in the cephalosporin C production of Acremonium chrysogenum in methionine-supplemented medium. Appl Microbiol Biotechnol 2013, 97 (6), 2551-62.
20. Liao G, Wang L, Liu Q, Guan F, Huang Y, Hu CH. Manipulation of kynurenine pathway for enhanced daptomycin production in Streptomyces roseosporus. Biotechnol Prog 2013, 29 (4), 847-52.
21. Wang L, Hu CH , Guojian Liao. Improvement of A21978C production in Streptomyces roseosporus by reporter-guided rpsL mutation selection. Journal of Applied Microbiology, 2012. 112(6):1095-101.
22. Zou X, Li B, Hu CH. Fed-batch fermentation for pleuromutilin production by Pleurotus mutilis. Research Journal of Biotechnology. 2012，7(1): 67-72.
23. Xiang LX, Zhou RM, Fu AL, Xu XR, Huang YQ, Hu CH. Targeted delivery of large fusion protein into hippocampal neurons through systemic administration. Journal of Drug Targeting. 2011, 19(8):632-6.
24. Hu CH, Deng Chao, Mackovski Nikolce, et al. Effects of simvastatin and 6-hydroxydopamine on histaminergic H1 receptor binding density in rat brains.Progress in Neuro- Psychopharmacology & Biological Psychiatry. 2010, 34(8):1419-1425.
25. Hu CH, Pai N, Huang XF, Deng C. Potential control of risperidone-induced cognitive deficits by adjunctive aripiprazole treatment. Journal of Clinical Psychopharmacology.2011, 31(1):135-136.
26. Xing W, Deng C, Hu CH. Molecular cloning and characterization of the global regulator LaeA in Penicillium citrinum. Biotechnology Letters, 2010, 32(11):1733-1737
27. Deng C, Chen JZ, Hu CH. What is the mechanism for aripiprazole’s effect on reducing olanzapine-induced obesity? Journal of Clinical Psychopharmacology.2010, 30(4).480
Students and young teachers who are interested in basic and developmental research related to drug biosynthesis and clinical pharmacy are welcome to join the research group.
