Xiaokang Zhu, Ph.D., Associate Professor
216,Tiansheng Road, Beibei,
College of Pharmaceutical Sciences, Southwest University
Chong Qing, P.R. China, 400716
Office: (+86)2368251225
Cell: (+86)18580501852
E-mail: zxk@swu.edu.cn
Research interest：
Our group focus on the construction of nano-medicine delivery system targeting CD44 and evaluation their anti-tumor activity in vitro and in vivo. We also did some works on the structure- activity relationship of Rhein derivatives.
Education
1998/09-2002/06，Southwest national University, Applied Chemistry, Bachelor
2002/09-2005/06，Sichuan University, organic chemistry, Master
2007/09-2011/06, Southwest University, Medicinal Chemistry, Ph.D.
2009/01-2009/04, Wrexham Glyndwr University, UK, Visiting Scholar
2014/01-2015/01, University of Manchester, UK, Visiting Scholar
2021/03-2021/06, University of Pennsylvania, Online Research and Academic Communication Skills Improvement Program
Work experience
2005-present Associate Professor, College of Pharmacy, Southwest University
l Teaching undergraduate chemistry and medicine, including medicinal chemistry , Drug’s synthesis and Organic Chemistry, Southwest University, PRC (07/2005-present)
l Advising undergraduate students with industrial practices.
l Guiding the thesis of undergraduate student with the design and experiment
Honor and Awards
The Outstanding Class adviser of Southwest University (2016)
The Outstanding Internship Instructor of Southwest University (2016)
The Outstanding Teacher for the 20th Anniversary of Online Education of Southwest University (2021)
Funds
1. National Natural Science Foundation of China Youth Program, 21602180, Research on the structure-activity relationship between the synthesis and anti-inflammatory activity of macrocyclic anthraquinone analogs targeting NF-κB, 2017/01-2019/12, PI
2. General project of Chongqing Natural Science Foundation, cstc2021jcyj-msxmX1026, co-loaded rhein and ferric oxide nanosystem for the diagnosis and treatment of triple negative breast cancer, 2021/10-2024/09, PI
3. Southwest University Fundamental Research Funding Project, XDJK2020C062, Design, Synthesis and Anti-inflammatory Activity of Rubialin Derivatives Targeting NF-кB/IKK, 2020/01-2022/12, PI
4. Southwest University Fundamental Research Funding Project, XDJK2016C071, Synthesis and Anti-inflammatory Activity of Macrocyclic Anthraquinone IκB Kinase Inhibitors, 2016/01-2017/12, PI
Selected publications:
1. Qifang Chen #, Xianbin Ma #, Li Xie, Wenjie Chen, Zhigang Xu, Erqun Song, Xiaokang Zhu*, Yang Song*. Iron-Based Nanoparticles for MR Imaging-Guided Ferroptosis in Combination with Photodynamic Therapy to Enhance Cancer Treatment. Nanoscale 2021,13: 4855-4870
2. Xuting Liu, Bin Lu, Juanli Fu, Xiaokang Zhu, Erqun Song, Yang Song*. Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells. J Hazard Mater. 2021, 404: 124050
3. Xiaokang Zhu*, Qifang Chen, Yujin Yang, Xixi Ai, Si Chen, Yang Song* Synthesis and anti-inflammatory effect of novel emodin derivatives bearing azole moieties. Arch Pharm 2020,353(2): 190026
4. Wenjing Dong, Qiushuang Zhu, Bingwei Yang, Qi Qin, Yawen Wang, Xiaomin Xia, Xiaokang Zhu, Zixuan Liu, Erqun Song, Yang Song.* Polychlorinated Biphenyl Quinone Induces Caspase 1‑Mediated Pyroptosis through Induction of Pro-inflammatory HMGB1-TLR4NLRP3-GSDMD Signal Axis. Chem Res Toxicol. 2019, 32(6):1051-1057
5. Yuxin Wang, Linyao Li, Yawen Wang, Xiaokang Zhu, Mingdong Jiang, Erqun Song , Yang Song. *New application of the commercial sweetener rebaudioside a as a hepatoprotective candidate: Induction of the Nrf2 signaling pathway. Eur J Pharmacol. 2018, 822:128-137.
6. David A Leigh*, Vanesa Marcos, Tugrul Nalbantoglu, Iñigo J Vitorica-Yrezabal, F Tuba Yasar, Xiaokang Zhu. Pyridyl-Acyl Hydrazone Rotaxanes and Molecular Shuttles. J Am Chem Soc. 2017, 139(20): 7104-7109
7. Li Ma, Konstantin A. Demin, Tatyana O. Kolesnikova, Sergey L. Kharsko, Xiaokang Zhu, Xiaodong Yuan, Cai Song, Darya A. Meshalkina, Brian E. Leonard, Li Tian & Allan V. Kalueff. Animal inflammation-based models of depression and their application to drug discovery. Expert Opinion on Drug Discovery. 2017,13-27
Patents
1. Xuegang Li, Xiaokang Zhu, Xiaoli Ye, 3-alkoxy-6-carboxyrhein or its pharmaceutically acceptable salt and its preparation method and application, ZL200910104466.5.
2. Xiaokang Zhu; Guangrong Zou; Qianxi Ai; Emodin derivatives and azole compounds and their preparation methods and applications, ZL201810040476.6
Welcomes excellent students join in our group, if your major is pharmacy, chemistry or materials science.
Email: zxk@swu.edu.cn; 2701247@qq.com
